Failure of neuronal protection by inhibition of glial activation in a rat model of striatonigral degeneration

Journal of Neuroscience Research
N StefanovaG K Wenning

Abstract

Previous studies in rodent models of neurodegenerative disorders have demonstrated that minocycline exerts neuroprotective effects unrelated to its antimicrobial action. The purpose of the present study was to analyze whether minocycline exhibits neuroprotective activity in a rat model of striatonigral degeneration (SND), the core pathology underlying levodopa-unresponsive parkinsonism associated with multiple system atrophy (MSA). We observed no significant effect of minocycline on locomotor impairment in double-lesioned SND rats. Minocycline significantly suppressed astroglial and microglial activation (P < 0.01); however, 3'5'-monophosphate-regulated phosphoprotein (DARPP 32) immunohistochemistry revealed no significant differences in striatal lesion volume of minocycline-treated versus untreated control SND rats. Furthermore, there was no protection of nigral dopaminergic neurons in the double-lesion model. We conclude that despite its astrocytic and microglial suppression, minocycline failed to attenuate lesion-induced neuronal damage in the SND rat model.

References

Aug 1, 1994·Brain : a Journal of Neurology·G K WenningN P Quinn
Sep 1, 1996·Movement Disorders : Official Journal of the Movement Disorder Society·G K WenningC D Marsden
Feb 11, 1999·Advances in Dental Research·M E Ryan, R A Ashley
Nov 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y DuS M Paul
Apr 17, 2002·Journal of Neural Transmission·G K WenningK Jellinger
Aug 2, 2003·Annals of Neurology·Donna L SmithEmma Hockly
Aug 22, 2003·Proceedings of the National Academy of Sciences of the United States of America·Xin WangRobert M Friedlander
Sep 30, 2003·Journal of Neuroscience Research·Lichuan YangDavid S Albers
Dec 19, 2003·Annals of Neurology·Elsa DiguetFrançois Tison
Jan 30, 2004·Lancet Neurology·Gregor K WenningWerner Poewe
Jan 30, 2004·Journal of Neuropathology and Experimental Neurology·Keisuke IshizawaTakanori Hirose

❮ Previous
Next ❯

Citations

May 13, 2011·Acta Neuropathologica·Lisa FellnerNadia Stefanova
Sep 4, 2012·Molecular Neurobiology·Lisa Fellner, Nadia Stefanova
Feb 11, 2016·Acta Neuropathologica Communications·Jonathan M BleaselWoojin Scott Kim
Jul 27, 2005·Trends in Neurosciences·Nadia StefanovaGregor K Wenning
Mar 7, 2014·Progress in Neurobiology·Daniela Kuzdas-WoodGregor K Wenning
Apr 15, 2014·Neurobiology of Disease·Pierre-Olivier FernagutWassilios G Meissner
Jan 15, 2015·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Nadia Stefanova, Gregor K Wenning
Sep 14, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Nadia StefanovaGregor K Wenning
Aug 9, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Matthew R Burns, Nikolaus R McFarland

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.