PMID: 2105989Mar 1, 1990Paper

Failure of nitroglycerin and diltiazem to reduce platelet-mediated vasoconstriction in dogs with coronary artery stenosis and endothelial injury: further evidence for thromboxane A2 and serotonin as mediators of coronary artery vasoconstriction in vivo

Journal of the American College of Cardiology
P GolinoJ T Willerson

Abstract

This study was designed to test the efficacy of nitroglycerin and diltiazem in inhibiting in vivo platelet aggregation and reducing platelet-mediated vasoconstriction in a canine model of coronary artery stenosis and endothelial injury. Coronary artery diameter was measured in vivo by means of ultrasonic crystals sutured on the left anterior descending coronary artery (LAD) immediately distal to an external constrictor (LAD1), 1 cm below (LAD2), and on the left circumflex coronary artery. Coronary diameter was continuously measured before, during cyclic flow variations (progressive declines in blood flow followed by sudden restorations of flow due to recurrent intracoronary platelet aggregation), during cyclic flow variations and intravenous infusion of nitroglycerin (5 micrograms/kg per min) or diltiazem (15 micrograms/kg per min), and after cyclic flow variations were abolished by administration of LY53857, a serotonin receptor antagonist (n = 7), or SQ29548, a thromboxane A2 receptor antagonist (n = 7). During control cyclic flow variations, at the nadir of coronary flow (6% to 11% of the nonstenosed values), LAD1 cross-sectional area decreased by 43 +/- 8% and 44 +/- 3% in the two groups of dogs subsequently treated with LY...Continue Reading

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Citations

Dec 31, 1997·Clinical Cardiology·V K MisraT A Fischell
Sep 1, 1991·Medicinal Research Reviews·S E Hall
Aug 18, 2006·Basic Research in Cardiology·Andreas SkyschallyGerd Heusch
Mar 1, 1990·Journal of the American College of Cardiology·J L Mehta
Nov 15, 1991·Journal of the American College of Cardiology·J D Folts
Dec 1, 1991·Trends in Cardiovascular Medicine·J S Stamler, J Loscalzo
Mar 6, 1998·International Journal of Cardiology·J D Folts
Jul 18, 2000·Journal of the American College of Cardiology·R Erbel, G Heusch
Mar 1, 1991·Journal of the American College of Cardiology·J L MehtaT G Saldeen
Feb 24, 1994·The New England Journal of Medicine·P GolinoJ T Willerson
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Apr 1, 1994·Circulation·K H BenzulyD D Heistad
Mar 26, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Andreas SkyschallyGerd Heusch

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