PMID: 9436564Jan 22, 1998Paper

Failure of preconditioning to improve postcardioplegia stunning of minimally infarcted hearts

The Annals of Thoracic Surgery
B FarisP Menasché

Abstract

Ischemic preconditioning is an effective means of reducing myocardial infarct size, but its ability to attenuate stunning after an episode of surgically relevant global ischemia remains elusive. Likewise, the role played by adenosine in this setting has not been established conclusively. This study was designed to address these two issues. Thirty isolated, crystalloid-perfused rabbit hearts were subjected to 60 minutes of normothermic potassium arrest and 60 minutes of reperfusion. They were divided into three equal groups. The first group had no prearrest intervention and served as a control. In the second group, ischemic preconditioning was achieved with 5 minutes of zero-flow ischemia followed by 5 minutes of buffer reperfusion before arrest. In the third group, the hearts were first infused for 5 minutes with the nucleoside transport inhibitor draflazine (10(-6) mol/L), the efficacy of which was demonstrated by reversal of the normally high inosine to adenosine ratio in the coronary effluent. These hearts subsequently were given 2 additional minutes of ischemic (zero-flow) preconditioning followed by 5 minutes of reperfusion before arrest. During reperfusion, function was measured serially under isovolumic conditions. Myoca...Continue Reading

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Citations

Feb 4, 2010·Basic Research in Cardiology·W J FanAmanda Lochner
Jun 23, 2001·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·Z K WuS Kaukinen
Dec 10, 1999·The Annals of Thoracic Surgery·L P Perrault, P Menasché
Feb 4, 1999·The Annals of Thoracic Surgery·J D McCullyS Levitsky
Feb 22, 2002·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Yoshihisa TanoueWillem Flameng
Apr 14, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Jason N Peart, John P Headrick
Apr 18, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·A EfstathiouA Lazou

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