PMID: 6402127Feb 12, 1983Paper

Failure of renal dopamine response to salt loading in chronic renal disease

British Medical Journal
I F CassonA D Clayden

Abstract

Eight patients with chronic glomerulonephritis and five age-matched normal volunteers were given additional sodium chloride by mouth under conditions of metabolic balance. Whereas in the normal volunteers plasma renin activity was suppressed and urinary excretion of free dopamine increased, in the patients dopamine was not mobilised and plasma renin activity was not completely suppressed. Abnormal retention of sodium and water in glomerulonephritis may be due partly to a failure to mobilise dopamine in the kidney. Specific renal dopamine agonists may be natriuretic and hypotensive in chronic glomerulonephritis.

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Citations

Oct 1, 1989·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·T TulassayK Schärer
Mar 29, 1984·The New England Journal of Medicine
Feb 24, 2005·Journal of Cardiovascular Pharmacology·Margarida AlvelosPatrício Soares-da-Silva
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·M R Lee
May 10, 2000·Clinical and Experimental Hypertension : CHE·P Soares-da-SilvaM Cerqueira-Gomes
Mar 1, 1985·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·L RuilopeJ L Rodicio
Sep 5, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A FerreiraP Soares-Da-Silva
Aug 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jens TitzeKarl August Kirsch
Aug 11, 2004·European Journal of Heart Failure·Margarida AlvelosPatrício Soares-Da-Silva
Jun 1, 1984·British Journal of Clinical Pharmacology·J N HarveyM R Lee
Nov 1, 1992·Annals of Clinical Biochemistry·P McClellandN B Roberts
Oct 3, 1999·Annals of Clinical Biochemistry·N B RobertsJ M Bone

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