PMID: 8583326Nov 1, 1995Paper

Failure of short-term luminal IGF-I to protect against atrophy in a model of fetal esophageal atresia

Journal of Pediatric Surgery
J F TrahairJ L Horn

Abstract

Short-term luminal infusion in utero (3 days) of insulin-like growth factor I (IGF-I) failed to protect the fetal small intestine against atrophy induced by ablation of swallowing. Human recombinant IGF-1 (or vehicle) was infused into the duodenum of fetal sheep at 125 days' gestation for 3 days (day 1, 0.025 mg; day 2, 0.25 mg: day 3, 2.5 mg). Fetal swallowing was prevented by esophageal ligation, and a carotid catheter was implanted for blood sampling. There were no changes in body growth of in major organ growth. Small intestinal (SI) weight (corrected for body weight) was significantly lower for IGF-I treated fetuses. Villus height decreased significantly in proximal regions. Villus enterocyte cellularity was reduced significantly in the proximal regions. The percentage of crypt cells labeled with a 4-hour pulse of tritiated thymidine (as assessed by autoradiography) decreased significantly in the proximal SI only, from 16.14% (1.06% SEM) to 13.28% (1.05% SEM) (P < .05). Plasma levels of IGF-1 increased in the treated fetuses by an average of 76%. IGF-1 immunoreactivity was detected in the apical endocytic complex of enterocytes from proximal SI. This study shows that wasting of fetal intestinal tissues in the absence of en...Continue Reading

References

Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·J F Trahair, R Harding
May 1, 1992·The Journal of Surgical Research·T L BuchmillerJ M Diamond
Jul 6, 1991·Lancet·P B SullivanN A Wright
Jan 1, 1991·Annual Review of Nutrition·D R Clemmons, L E Underwood
Jan 1, 1991·Journal of Pediatric Gastroenterology and Nutrition·C G Avila, R Harding
Jun 1, 1987·Clinical and Experimental Pharmacology & Physiology·A ShulkesK J Hardy
Jul 1, 1986·Journal of Pediatric Gastroenterology and Nutrition·J F TrahairP M Robinson
Jan 1, 1986·Biology of the Neonate·J F TrahairP M Robinson
Jan 1, 1986·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·J F TrahairP M Robinson
Oct 1, 1984·The Journal of Clinical Endocrinology and Metabolism·T J MerimeeJ E Tyson
Jul 1, 1984·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·R HardingP J Wickham
Aug 1, 1984·The Journal of Clinical Endocrinology and Metabolism·D J HillR D Milner
Feb 1, 1995·Journal of Pediatric Gastroenterology and Nutrition·J F Trahair, R Harding
Dec 1, 1993·Endocrine Reviews·C E GrosvenorC R Baumrucker
Jan 1, 1993·Virchows Archiv. A, Pathological Anatomy and Histopathology·J F TrahairW D Ford
Jul 1, 1993·American Journal of Obstetrics and Gynecology·T H Hakala-Ala-PietiläM T Seppälä
Jan 1, 1993·JPEN. Journal of Parenteral and Enteral Nutrition·J F Trahair

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Citations

Apr 21, 2009·Tissue Engineering. Part C, Methods·Amulya K SaxenaMichael E Höllwarth
Feb 28, 2002·Pediatric Research·Frank H BloomfieldJane E Harding
Dec 24, 2008·Seminars in Pediatric Surgery·Adonis S Ioannides, Andrew J Copp
Jul 18, 2008·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·D M KarcherT J Applegate
Jun 1, 1997·Equine Veterinary Journal. Supplement·J F Trahair, P T Sangild

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