Failure of somatostatin to affect human chorionic somatomammotropin and human chorionic gonadotropin secretion in vitro

The Journal of Clinical Endocrinology and Metabolism
C MacaronJ Brewer

Abstract

The effect of somatostatin (SRIF) on human chorionic somatomammotropin (hCS) secretion was studied in human placental explants cultured in vitro. In the experimental flasks, SRIF was added in a concentration of 10, 100, and 1000 ng/ml media; hCS levels measured by RIA were not different from those found in the control flasks. In separate experiments, we investigated the action of SRIF on hCG secretion by a human malignant choriocarcinoma cell line maintained in tissue culture. SRIF (1000 ng/ml) did not inhibit basal or dibutyryl cAMP-induced stimulation of hCG secretion. These results suggest that somatostatin does not suppress hCS or hCG release in vitro from normal or malignant trophoblast, respectively.

Citations

Jul 1, 1991·Molecular and Cellular Endocrinology·F Petraglia
Feb 1, 1988·Biochemical Medicine and Metabolic Biology·Z HochbergR Perlman
Jan 1, 1991·Annals of the New York Academy of Sciences·T Chard
Apr 1, 1990·Journal of Endocrinological Investigation·F PetragliaS Angioni

Related Concepts

Choriocarcinoma
Bucladesine, Barium (1: 1) Salt
Pregnyl
Organ Culture Techniques
Placenta
Human Placental Lactogen
Stilamin
Uterine Cancer

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