Failure of suppression of intrarenal angiotensin II in the contralateral kidney of one-clip two-kidney hypertensive rats

Clinical and Experimental Pharmacology & Physiology
F A Mendelsohn

Abstract

1. Two-kidney one-clip hypertension was produced in rats by application of a 0.20 mm clip to the left renal artery. 2. After three weeks, the animals had mildly elevated PRA, kidney renin was elevated in the clipped kidney and markedly suppressed in the contralateral kidney when compared to values in sham-operated rats. 3. Intrarenal AII was elevated in the clipped kidney either when compared to the contralateral kidney or to values in the controls. However, in the contralateral kidney, AII was not different from controls. 4. Changes in intrarenal AII do not, therefore, always parallel those of renal renin. Failure of suppression of AII in the contralateral kidney is likely to be of pathogenetic importance in development of hypertension in this experimental model.

References

Feb 1, 1977·Circulation Research·H M KimbroughC R Ayers
Aug 1, 1976·Clinical Science and Molecular Medicine·F A Mendelsohn
Jun 1, 1975·Circulation Research·O P GulatiA Schork
Jul 1, 1972·Canadian Journal of Physiology and Pharmacology·W H Waugh
Jan 1, 1969·Circulation Research·D J Patel, D L Fry

❮ Previous
Next ❯

Citations

Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·A Gillies, T Morgan
Oct 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D W Ploth, W Fitzgibbon
Jul 10, 2002·Hypertension·Hirobumi TokuyamaTakao Saruta
Sep 20, 2012·Pflügers Archiv : European journal of physiology·Minolfa C PrietoL Gabriel Navar
Jan 5, 2010·Journal of the American Society of Hypertension : JASH·Minolfa C Prieto-CarrasqueroL Gabriel Navar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.