Failure of zafirlukast to prevent ibuprofen-induced anaphylaxis

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
R MenendezG Ortiz

Abstract

Anaphylaxis to nonsteroidal anti-inflammatory drugs is thought to depend on cycloxygenase inhibition coupled to upregulation of 5-lipoxygenase-dependent pathways. The introduction of leukotriene-receptor antagonists afforded the opportunity to test this hypothesis. These agents provide at least partial protection against aspirin-induced anaphylaxis during controlled challenges but we did not know whether the level of protection was high enough to block symptoms from ingestion of a full dose of aspirin. We report a patient with moderately severe asthma who experienced an episode of anaphylaxis following ingestion of 400 mg of ibuprofen while under therapy with 20 mg of zafirlukast given twice a day. No further episodes of anaphylaxis have been noted following institution of complete avoidance to all nonsteroidal anti-inflammatory drugs. Patients who are sensitive to cycloxygenase inhibitors should practice complete avoidance of these drugs even while under therapy with leukotriene modifiers.

References

Dec 1, 1991·The Journal of Allergy and Clinical Immunology·J V BossoD D Stevenson
Oct 1, 1991·The American Review of Respiratory Disease·P E ChristieT H Lee
Dec 1, 1993·The American Review of Respiratory Disease·T H Lee
Dec 1, 1993·The American Review of Respiratory Disease·E IsraelJ M Drazen

❮ Previous
Next ❯

Citations

Jun 25, 1999·Allergy·E EnriqueM M San Miguel
Feb 24, 2001·Pediatric Dermatology·M Díaz JaraM I Martínez Molero
Apr 10, 2002·American Journal of Therapeutics·Andrew SzczeklikZsuzsanna Szabo
Nov 21, 2000·Postgraduate Medical Journal·O J Dempsey
Sep 29, 2004·Paediatric Drugs·Ralph E Kauffman, Mary Lieh-Lai
May 9, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Paul A Greenberger, Phillip Lieberman
Jun 1, 2000·Indian Journal of Pediatrics·G Gupta
Jul 1, 2002·Medical Journal, Armed Forces India·Girish GuptaC G Wilson
May 5, 2001·Expert Opinion on Pharmacotherapy·M E Krawiec, S E Wenzel
Aug 23, 2005·Expert Opinion on Drug Safety·Mario Sánchez-BorgesFernan Caballero-Fonseca
May 5, 2001·Expert Opinion on Pharmacotherapy·L García-Marcos, A Schuster
Apr 20, 2002·Current Opinion in Allergy and Clinical Immunology·A SzczeklikM Swierczynska
May 19, 2017·Paediatric Drugs·Victoria C ZiesenitzJohannes N van den Anker
Jun 28, 2000·Biopharmaceutics & Drug Disposition·R I ShaderD J Greenblatt
Aug 31, 2019·Allergy·Inmaculada DoñaJosé Antonio Cornejo-García
Dec 11, 1999·Proceedings of the Association of American Physicians·J M Drazen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.