Failure patterns in patients with esophageal cancer treated with definitive chemoradiation.

Cancer
James WelshJaffer A Ajani

Abstract

Local failure after definitive chemoradiation therapy for unresectable esophageal cancer remains problematic. Little is known about the failure pattern based on modern-day radiation treatment volumes. We hypothesized that most local failures would be within the gross tumor volume (GTV), where the bulk of the tumor burden resides. We reviewed treatment volumes for 239 patients who underwent definitive chemoradiation therapy and compared this information with failure patterns on follow-up positron emission tomography (PET). Failures were categorized as within the GTV, the larger clinical target volume (CTV, which encompasses microscopic disease), or the still larger planning target volume (PTV, which encompasses setup variability) or outside the radiation field. At a median follow-up time of 52.6 months (95% confidence interval, 46.1-56.7 months), 119 patients (50%) had experienced local failure, 114 (48%) had distant failure, and 74 (31%) had no evidence of failure. Of all local failures, 107 (90%) were within the GTV, 27 (23%) were within the CTV, and 14 (12%) were within in the PTV. On multivariate analysis, GTV failure was associated with tumor status (T3/T4 vs T1/T2; odds ratio, 6.35; P = .002), change in standardized uptake...Continue Reading

References

Dec 1, 1987·International Journal of Radiation Oncology, Biology, Physics·M CaudryH Azaloux
Jan 18, 1995·Journal of the National Cancer Institute·L M BrownA G Schwartz
Aug 15, 1996·The New England Journal of Medicine·T N WalshT P Hennessy
Jul 14, 1999·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M K MartelA S Lichter
Mar 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce D MinskyDavid P Kelsen
Jul 20, 2002·International Journal of Radiation Oncology, Biology, Physics·Alan PollackIsaac Rosen
Jan 20, 2005·Journal of the National Cancer Institute·Heiko Pohl, H Gilbert Welch
Feb 10, 2006·The New England Journal of Medicine·James A BonnerK Kian Ang
Aug 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David P KelsenUNKNOWN USA Intergroup
Aug 21, 2007·International Journal of Radiation Oncology, Biology, Physics·Lawrence B Marks, Jinli Ma
Sep 11, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lawrence Kleinberg, Arlene A Forastiere
Sep 25, 2007·International Journal of Radiation Oncology, Biology, Physics·Ylanga G van der GeldFrank J Lagerwaard
Mar 4, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joel TepperRobert Mayer
Aug 13, 2008·Journal of the National Cancer Institute·Linda Morris BrownWong-Ho Chow
Aug 1, 2009·Expert Opinion on Investigational Drugs·Wooin LeeA Craig Lockhart
Sep 15, 2010·International Journal of Cancer. Journal International Du Cancer·Lingyun Wei, Zhifei Xu
Jan 22, 2011·International Journal of Radiation Oncology, Biology, Physics·Joe Y ChangJames D Cox
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin

❮ Previous
Next ❯

Citations

Sep 10, 2013·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·I LazarescuB Dubray
May 27, 2014·International Journal of Oncology·Soichiro HonjoShumei Song
Apr 20, 2014·BMC Cancer·Nam P NguyenUNKNOWN International Geriatric Radiotherapy Group
Jan 10, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yongshun ChenYou Lu
Mar 13, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Wei-Wei YuJames Welsh
Jun 22, 2014·World Journal of Surgery·Yasunori AkutsuHisahiro Matsubara
Jan 1, 2012·Seminars in Thoracic and Cardiovascular Surgery·Jae Y Kim, Wayne L Hofstetter
Dec 29, 2012·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·D RousseauN Mesgouez-Nebout
Nov 28, 2012·The Annals of Thoracic Surgery·Rodney J Landreneau
Mar 5, 2016·International Journal of Clinical Oncology·Katsuyuki SakanakaMasahiro Hiraoka
Sep 10, 2014·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·G CréhangeP Maingon
Apr 9, 2016·Journal of the Chinese Medical Association : JCMA·He-Yuan HsiehChen-Fa Chang
Aug 1, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Coraline BednarekStéphanie Servagi Vernat
Aug 4, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Peng ZhangMeng-Zhong Liu
Apr 15, 2014·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·E VersteijneM C C M Hulshof
Apr 30, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yongshun ChenYou Lu
Jan 15, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Wen YuXiao-Long Fu
Jul 8, 2014·Clinical Oncology : a Journal of the Royal College of Radiologists·J M WilsonM Hawkins
Oct 12, 2014·International Journal of Radiation Oncology, Biology, Physics·Samantha WarrenMaria A Hawkins
Sep 21, 2016·Best Practice & Research. Clinical Gastroenterology·M C C M Hulshof, H W M van Laarhoven
Oct 16, 2016·World Journal of Surgical Oncology·Cengiz GemiciAlpaslan Mayadagli
Oct 22, 2016·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·P M JeeneM C C M Hulshof
Oct 30, 2016·Journal of Surgical Oncology·Eleonora FarinellaIssam El Nakadi
May 29, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kazuki SudoJaffer A Ajani
Sep 17, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kazuki SudoJaffer A Ajani
Jul 2, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brian G CzitoChristopher G Willett
Feb 25, 2017·International Journal of Cancer. Journal International Du Cancer·Takahito SugaseTetsuji Naka
Oct 27, 2018·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Marcel NachbarCihan Gani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Radiation Oncology, Biology, Physics
James WelshRitsuko Komaki
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Christopher G Willett
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Laurent BedenneChristine Binquet
Cancer radiothérapie : journal de la Société française de radiothérapie oncologique
D RousseauN Mesgouez-Nebout
© 2021 Meta ULC. All rights reserved