Failure to confirm genetic association between schizophrenia and markers on chromosome 1q23.3 in the region of the gene encoding the regulator of G-protein signaling 4 protein (RGS4)

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Mie A RizigHugh Gurling

Abstract

The chromosome 1q23.3 region, which includes the RGS4 gene has been implicated in genetic susceptibility to schizophrenia by two linkage studies with lod scores of 6.35 and 3.20 and with positive lod between 2.00 and 3.00 scores in several other studies. Reduced post mortem RGS4 gene expression in the brain of schizophrenics was reported as well as positive allelic association between markers at the RGS4 gene locus and schizophrenia. We have attempted to replicate the finding of allelic association with schizophrenia in a UK based sample of 450 subjects with schizophrenia and 450 supernormal controls. We genotyped the same SNP marker alleles investigated in the earlier studies and also a di-nucleotide (GT)14 repeat microsatellite marker, which was 7 kb distal to RGS4. In the new UK sample there was no evidence for allelic or haplotypic association between RGS4 markers and schizophrenia. This might reflect genetic heterogeneity between the population samples, genotyping or other methodological problems. The finding weakens the evidence that mutations or variation in the RGS4 gene have an effect on schizophrenia susceptibility.

References

Apr 24, 1995·American Journal of Medical Genetics·N S KosowerB Lerer
Oct 1, 1998·American Journal of Medical Genetics·S H ShawL E DeLisi
May 9, 2000·Human Heredity·J H ZhaoP C Sham
May 18, 2000·Human Molecular Genetics·J K MillarD J Porteous
Jul 27, 2001·Human Molecular Genetics·J EkelundL Peltonen
May 25, 2002·Human Molecular Genetics·Kodavali V ChowdariVishwajit L Nimgaonkar
Dec 20, 2002·Bioinformatics·Jing Hua ZhaoPak Chung Sham
May 13, 2003·Molecular Psychiatry·H-G HwuS F-C Lee
Jan 21, 2004·Biological Psychiatry·Nigel M WilliamsMichael C O'Donovan
Feb 3, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Derek W MorrisAiden P Corvin
Jun 16, 2004·Molecular Psychiatry·J EkelundL Peltonen
Jul 27, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Xiangning ChenKenneth S Kendler

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Citations

May 14, 2008·Current Psychiatry Reports·Jennifer Gladys Mulle
May 23, 2007·Schizophrenia Bulletin·Kodavali V ChowdariVishwajit L Nimgaonkar
Oct 8, 2014·Molecular Psychiatry·T G DinanJ F Cryan
Jan 25, 2016·European Psychiatry : the Journal of the Association of European Psychiatrists·J SolerM Fatjó-Vilas
Jan 24, 2012·Biological Psychiatry·Jennifer Joeyen-WaldorfEtienne Sibille
Feb 12, 2008·Schizophrenia Research·Daniel B CampbellPatrick F Sullivan
Jan 1, 2009·Progress in Molecular Biology and Translational Science·David L Roman
May 26, 2017·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Emanuel Schwarz
Oct 11, 2007·Molecular Psychiatry·G KaroutzouD E Dietrich
Jun 19, 2007·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Stephan ZüchnerJean C Beckham
Aug 28, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Hon-Cheong SoPak C Sham

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