PMID: 8590316Feb 1, 1995Paper

Failure to detect type 1 interferon production in human umbilical cord vein endothelial cells after viral exposure

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
P NeustockH Kirchner

Abstract

Cytokine production by endothelial cells is known to occur after the reception of signals such as interleukin-1 (IL-1) and tumor necrosis factor (TNF). In the present study, we demonstrate cytokine release and upregulation of adhesion molecule expression of human endothelial cells derived from umbilical cord veins in response to stimulants. The cells were exposed to the plant lectin phytohemagglutinin A (PHA), the viral inducers Newcastle disease virus (NDV) and Sendai virus, and the nucleic acid analog polyinosinic/polycytidylic acid (polyI:C). All stimulants induced expression of IL-1 beta and IL-6. The titers of these cytokines were comparable to those obtained in human leukocytes, whereas no TNF-alpha release was detectable. A further feature of activation was upregulation of intercellular adhesion molecule 1 (ICAM-1), which was analyzed after contact with these stimulants. These experiments revealed an increased expression of ICAM-1 in response to all stimulants tested. A major part of our studies was devoted to the ability of endothelial cells to produce interferons as an important function of a number of cell types in response to viral infections. To ensure stimulation of the cells, the inducers NDV, Sendai virus, and po...Continue Reading

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Citations

Feb 19, 2000·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·J G Sinkovics, J C Horvath
Jul 18, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Holger HägeleHans-Joachim Anders
Dec 14, 1999·The Journal of Laboratory and Clinical Medicine·F L VisserenD W Erkelens
Aug 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Itaru IshidaTakashi Kondo

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