Failure to direct detect magnetic field dephasing corresponding to ERP generation

Magnetic Resonance Imaging
Lin TangJohn C Gore

Abstract

Functional magnetic resonance imaging (fMRI) has become the method of choice for mapping brain activity in human subjects and detects changes in regional blood oxygenation and volume associated with local changes in neuronal activity. While imaging based on blood oxygenation level dependent (BOLD) contrast has good spatial resolution and sensitivity, the hemodynamic signal develops relatively slowly and is only indirectly related to neuronal activity. An alternative approach termed magnetic source magnetic resonance imaging (msMRI) is based on the premise that neural activity may be mapped by magnetic resonance imaging (MRI) with greater temporal resolution by detecting the local magnetic field perturbations associated with local neuronal electric currents. We used a hybrid ms/BOLD MRI method to investigate whether msMRI could detect signal changes that occur simultaneously at the time of the production of well-defined event-related potentials, the P300 and N170, in regions that previously have been identified as generators of these electrical signals. Robust BOLD activations occurred after some seconds, but we were unable to detect any significant changes in the T2*-weighted signal in these locations that correlated temporally...Continue Reading

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Citations

Apr 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Nicholas W Halpern-MannersAlexander Pines
Feb 24, 2016·NeuroImage·Padmavathi SundaramYoshio Okada
Mar 11, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xia JiangJia-Hong Gao
May 26, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yiqun XueJinhu Xiong
Apr 3, 2009·Annals of the New York Academy of Sciences·Peter A Bandettini
Jan 22, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Qingfei LuoJia-Hong Gao
Jul 21, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Qingfei LuoJia-Hong Gao
Dec 5, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xia JiangJia-Hong Gao
Oct 3, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mukund BalasubramanianDarren B Orbach
Mar 12, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jie Huang
Aug 22, 2015·Interdisciplinary Sciences, Computational Life Sciences·Seyed Mehdi BagheriMofidiAli Abbaspour Tehrani-Fard
Sep 3, 2016·Australasian Physical & Engineering Sciences in Medicine·Seyed Mehdi BagheriMofidiAli Abbaspour Tehrani-Fard
Sep 3, 2010·Physics in Medicine and Biology·Ying-Ling HuangDe-Zhong Yao
Jan 18, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Trong-Kha TruongAllen W Song

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