PMID: 11343976May 10, 2001Paper

Failure to down-regulate intragraft cytokine mRNA expression shortly after clinical heart transplantation is associated with high incidence of acute rejection

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
H A de Groot-KrusemanW Weimar

Abstract

Brain-death, ischemia and reperfusion damage have been implicated as initial factors that lead to a cascade of immunologic events that result in allograft rejection in experimental animals. Cytokines are thought to play a central role in this process. Therefore, we evaluated intragraft cytokine mRNA expression at an early stage after clinical heart transplantation and related these data to ischemia, immunosuppression, and rejection. We sampled endomyocardial biopsies at 30 minutes (EMB 0) and at 1 week (EMB 1) after transplantation from 20 cardiac allograft recipients. Intragraft monocyte chemoattractant protein (MCP-1) and basic fibroblast growth factor (bFGF) mRNA expression levels were quantitatively measured using competitive template Reverse-transcriptase polymerase chain reaction (RT-PCR). We measured significantly lower MCP-1 and bFGF mRNA expression levels in EMB 1 compared with EMB 0 (MCP-1, p = 0.006; bFGF, p = 0.019). We found no direct correlation between the cytokine mRNA expression levels in EMB 0 or EMB 1 and ischemic times, induction therapy, or cyclosporine whole-blood trough levels. Patients with a high incidence of acute rejection episodes (>2 in the first year) had higher bFGF mRNA expression levels (p = 0.0...Continue Reading

References

Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M E RussellM J Karnovsky
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Citations

Jul 7, 2005·The Journal of Thoracic and Cardiovascular Surgery·Jonah OdimDavid Gjertson
May 10, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Andrey MorgunMaria Gerbase-DeLima
Aug 5, 2015·Clinical Biochemistry·Clara Crescioli
Dec 11, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S AharinejadM Grimm
Jul 2, 2009·Clinical Science·Jianli Niu, Pappachan E Kolattukudy

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