PMID: 6407254May 1, 1983Paper

Failure to find evidence of immunoglobulin inhibitor(s) of thyroid hormone binding to serum proteins in non-thyroid illnesses

Acta Endocrinologica
S BenvengaF Trimarchi

Abstract

In order to verify the hypothesis of the presence of IgM (or an IgM-like substance) capable of inhibiting thyroid hormone binding to serum proteins and, therefore, capable of enhancing serum free thyroid fractions in non-thyroid illnesses (NTI), we measured TBG and TBPA maximum binding capacities and TBG concentration by an immunoradiometric system in normal pooled sera (NPS) before and after enrichment with purified immunoglobulins (IgM and IgG) from euthyroid NTI sera (free T4, free T3 and TSH levels were normal). A known amount of TBG was diluted 1:2-1:6 with deionized water or with IgM from NPS or from each of 6 NTI sera; the measured values were not different from these expected on theoretical grounds. Likewise, IgM or IgG from normal or from each of 7 NTI sera failed to modify both TBG and TBPA capacities of different NPS, and NTI immunoglobulins showed no binding activity directed to [125I]T4, [125I]T3 or [125I]TBG. In addition, no inhibitory influence of TBG and TBPA capacities was observed when the whole euglobulin fraction obtained by precipitating the same 7 NTI sera by PEG was mixed with NPS. On the other hand, a significant IgM inhibitory effect on the binding of labelled T4 to TBG was found, only when IgM concentr...Continue Reading

Citations

Jan 13, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·S H TikanojaB K Liewendahl
Dec 1, 1987·Journal of Endocrinological Investigation·S BenvengaJ Robbins

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