Failure to induce hypersensitivity reactions to opaque contrast media analogs in guinea pigs.

Investigative Radiology
C R DunnJ Lang

Abstract

In a further exploration of idiosyncratic reactions to injections of contrast media, a systematic study of immediate or delayed hypersensitivity in guinea pigs injected with contrast media analogs was performed. No evidence of immediate or delayed hypersensitivity could be ascertained to either contrast media analogs alone, or analogs bound to protein carriers. This does not represent conclusive evidence against the notion of antibody formation as a factor in the production of some adverse reactions, but makes such a pathogenesis less likely.

Citations

Jun 1, 1984·The British Journal of Radiology·D H Carr, A C Walker
Jul 1, 1991·European Journal of Radiology·F RasmussenJ Georgsen
Mar 1, 1985·The Journal of Allergy and Clinical Immunology·J E ErffmeyerP Lieberman
May 1, 1986·Acta Radiologica: Diagnosis·T Olin
May 1, 1986·Clinical Reviews in Allergy·P LiebermanG Treadwell

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