Failure to monoaminergic and cholinergic receptor blockers to prevent prostaglandin E2-induced luteinizing hormone release

Endocrinology
P G HarmsS M McCann

Abstract

Receptor blocking drugs were used to determine whether adrenergic, dopaminergic, serotoninergic, or cholinergic synapses are involved in mediating the LH release induced by intraventricularly injected PGE2. Prostaglandin E2 (5mug) was injected into the 3rd ventricle (3rd V) of ovariectomized rats, and plasma LH concentrations before and after treatment were determined by radioimmunoassay. Phentolamine, 20 or 30 mug, or pronethalol, 20 mug (alpha and beta adrenergic receptor blockers, respectively) injected into the 3rd V failed to alter the elevation of plasma LH evoked by PGE2 injected into the ventricle 10 min later. Likewise, LH release following PGE2 was not changed when a dopaminergic blocker, pimozide (0.63 mg/kg, SC), was injected 2 h prior to PGE2. Two antagonists of serotonin, methysergide maleate (3 mg/kg ip) or cinanserin HC1 (1 mg/kg iv) given 2 h or 45 min before PGE2, respectively, failed to alter the action of PGE2. Atropine (100 or 250 mug) injected into the 3rd V 10 min prior to PGE2 was also ineffective in blocking the increase in plasma LH following PGE2. The results of this study indicate that the effect of PGE2 on LH release is not mediated by adrenergic, dopaminergic, serotoninergic, or cholinergic recepto...Continue Reading

Citations

May 1, 1987·Molecular and Cellular Endocrinology·L KieselB Runnebaum
Jan 4, 1979·Biochimica Et Biophysica Acta·A A LicataF C Bartter
Jun 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A M Cowell, J C Buckingham
Jul 1, 1995·Trends in Endocrinology and Metabolism : TEM·M Bergendahl, J D Veldhuis
Oct 1, 1977·Clinical Endocrinology·G OppizziP G Chiodini
Jan 1, 1989·Annals of the New York Academy of Sciences·S R OjedaJ Capdevila
Jul 1, 2017·Journal of Neuroendocrinology·P N SurkinJ Fernández-Solari

Related Concepts

Atropen
Cinanserin Hydrochloride
Ethanolamines
5-Hydroxytryptophan
Luteozyman
Sansert
Z-Max
Antalon
Prostaglandins E
Norepinephrine Receptors

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