PMID: 6403201Feb 21, 1983Paper

Failure to replicate the dorsal bundle extinction effect: telencephalic norepinephrine depletion does not reliably increase resistance to extinction but does augment gustatory neophobia

Brain Research
T N TombaughC Szostak

Abstract

Depletion of telencephalic noradrenaline (Ne), caused by lesion of the dorsal tegmental bundle, has been reported to increase persistence of non-reinforced responding in various operant tasks. This has been referred to as the dorsal bundle extinction effect (DBEE). In an effort to reproduce this effect, rats receiving 6-hydroxydopamine lesions of the dorsal Ne bundle (DB-6-OHDA) were compared to controls during extinction of a continuous food rewarded (CRF) lever-press response. While the lesion group showed an increase in responding during initial extinction, no significant difference in resistance to extinction using a 2-min non-response criterion was obtained. Moreover, no differences in reinforced response rates were observed with CRF, fixed ratio (FR-15, FR-30, FR-60) or variable interval (VI-30, VI-60, VI-120 s) schedules of reinforcement. In order to test the hypothesis that the DBEE is dependent on time of behavioral testing after surgery, subsequent experiments were performed where rats began CRF operant training 5, 17, 31 or 110 days post-lesion. No differences in resistance to extinction were observed between lesion and control rats at any post-lesion interval. Neonatal treatment with 6-OHDA which permanently lesions...Continue Reading

References

Feb 1, 1977·Journal of Comparative and Physiological Psychology·S T Mason, S D Iversen
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Jul 1, 1979·Brain Research·S T Mason, S D Iversen
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Jun 1, 1978·Physiology & Behavior·S T Mason, S D Iversen
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Dec 4, 1975·Nature·S T Mason, S D Iversen
Mar 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·D Kirk

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Citations

Jan 1, 1992·Psychopharmacology·J D SteketeeA C Swann
Jan 1, 1987·Physiology & Behavior·E BrennerJ Van der Gugten
Oct 1, 1989·Physiology & Behavior·J D SteketeeA C Swann
Aug 1, 1988·Pharmacology, Biochemistry, and Behavior·M PisaH C Fibiger
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·S T Mason
Mar 1, 1987·Neurobiology of Aging·S Y FeltenD L Felten
Nov 1, 1989·Neurobiology of Aging·M Gallagher, R D Burwell
Nov 1, 1991·Neurobiology of Aging·T J Collier, P D Coleman

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