PMID: 6402867Feb 1, 1983Paper

Failure to secrete immunoreactive insulin by rats fed a low protein diet

Acta Endocrinologica
L S LevineF Marcus

Abstract

Rats fed a 6% protein diet for 14 weeks showed a normal glucose tolerance but failed to release immunoreactive insulin (IRI), following iv glucose. Furthermore the isolated perfused pancreas of the rats fed the 6% protein diet secreted eleven times less IRI than the isolated pancreas prepared from the rats reared on an 18% protein diet when both were subjected to the same glucose challenge. This difference occurred despite the fact that the total IRI content of the pancreas' was not significantly different between the two groups. In the protein-malnourished rats it is suggested that the normal glucose tolerance response, despite the failure to release a concommitant amount of IRI, may indicate increased sensitivity to IRI or may be due to the secretion in these animals of a biologically active insulin, which shows no immunological cross-reactivity with pancreatic insulin. Alternately there may be increased peripheral glucose utilisation in the low protein rats.

Citations

Nov 1, 1985·Molecular and Cellular Endocrinology·K D KohnertH Hahn von Dorsche
Nov 1, 1988·The British Journal of Nutrition·W OkitolondaJ C Henquin
Apr 28, 2004·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·E HaradaT Takeuchi
Jan 1, 1991·Annals of Tropical Paediatrics·S A AdegbenroM A Fafunso
May 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·C AlvarezB Portha
Sep 1, 1986·The American Journal of Physiology·J H ParkJ A Vanderhoof
Jan 14, 1999·The American Journal of Physiology·M J Holness, M C Sugden

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