PMID: 8608175Mar 1, 1996Paper

Failure to withstand oxidative stress induced by phospholipid hydroperoxides as a possible cause of the lens opacities in systemic diseases and ageing

Biochimica Et Biophysica Acta
Mark A Babizhayev

Abstract

Lipid peroxidation (LPO) is a causative factor of cataract. The increased concentrations of primary molecular LPO products (diene conjugates, lipid hydroperoxides) and end fluorescent LPO products, were detected in the lipid moieties of the aqueous humor samples obtained from patients with senile and complicated cataracts as compared to normal donors. The degrees of lens clouding were assessed quantitatively by measuring the optical density indices and areas of equidensities using digital image analysis. Human cataractous lenses showed decreased activity of glutathione peroxidase (GPX, catalyzing reduction of organic hydroperoxides including hydroperoxides of lipids). The apparent Km for tert-butylhydroperoxide was 0.434 mM for human normal and cataractous lens GPX. When lenses were exposed for 1 h at 37 degrees C to linoleic acid hydroperoxide (LOOH, 0.5 mM) or egg phosphatidyl-choline hydroperoxide (PLOOH, 1 micro mol per 112 micro mol of phospholipid) in liposomes suspended in the incubation medium, normal, immature and mature human cataractous lenses showed a significant loss in the residual content of liberated LOOH to 62%, 38% or 17%, correspondingly, but little or no reduction was observed with PLOOH in liposomal membran...Continue Reading

References

Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A Spector, D Roy
Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S D VarmaR D Richards
May 1, 1992·Current Eye Research·S Baghieri, M H Garner
Oct 1, 1992·Experimental Eye Research·M A BabizhayevA A Sologub
Apr 1, 1992·Lipids·D BorchmanM C Yappert
Jan 16, 1992·Biochimica Et Biophysica Acta·M A BabizhayevA V Chernikov
Jan 1, 1989·Free Radical Biology & Medicine·J S ZiglerX Y Du
May 1, 1989·Journal of Microscopy·M A BabizhayevV I Derevyagin
Aug 1, 1989·Experimental Eye Research·F SimonelliG Auricchio
Dec 1, 1985·Experimental Eye Research·R N WilliamsC A Paterson
Jul 1, 1988·Mechanisms of Ageing and Development·M A BabizhayevL F Linberg
Apr 1, 1988·American Journal of Clinical Oncology·A R KaganA Norman
Mar 1, 1984·Current Eye Research·P S KulkarniB D Srinivasan
May 11, 1984·Biochimica Et Biophysica Acta·R J Cenedella
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·M H Garner, A Spector
Jan 1, 1994·Experimental Eye Research·H MibuM Hikida
Feb 22, 1994·Biochimica Et Biophysica Acta·M A Babizhayev, E B Costa

❮ Previous
Next ❯

Citations

Jul 7, 2011·Indian Journal of Clinical Biochemistry : IJCB·P P SinghPraveen Sharma
Oct 15, 1996·Clinica Chimica Acta; International Journal of Clinical Chemistry·M A BabizhayevG A Zheltukhina
Apr 15, 2003·Chemistry and Physics of Lipids·Elena M Oborina, M Cecilia Yappert
Nov 20, 2001·Ophthalmology·C R GaleC N Martyn
Feb 14, 2002·Free Radical Biology & Medicine·S ChoudharyN H Ansari
Jan 16, 1999·Free Radical Biology & Medicine·R NealN Ercal
Apr 10, 1999·The Journal of Pharmacy and Pharmacology·M D Coleman, C V Rustioni
Mar 1, 2011·Medical Hypotheses·Aharon Wegner, Ramin Khoramnia
Jul 12, 2008·Experimental Eye Research·M J CostelloDorairajan Balasubramanian
Nov 26, 2009·Journal of Molecular Recognition : JMR·Junjie XuGuangjun Nie
Oct 2, 2015·Aging and Disease·José H CararoGustavo da C Ferreira
Jun 25, 2008·Journal of Molecular Recognition : JMR·Rui HuoGuimin Luo
Jan 5, 2011·Journal of Inorganic Biochemistry·Nan GaoGuimin Luo
Mar 1, 2012·Oxidative Medicine and Cellular Longevity·Bojana KisicIlija Dragojevic
May 19, 2004·The Journal of Biological Chemistry·Ye SunGuimin Luo
Apr 21, 2010·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Julien OliveChristine Theoret
Dec 6, 2011·Amino Acids·Umberto TarantinoAugusto Orlandi
May 1, 2012·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Valerie Simon, Sue J Dyson
Jul 6, 2013·Equine Veterinary Journal·M T AlberT N Trumble

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.