FairBase: a comprehensive database of fungal A-to-I RNA editing

Database : the Journal of Biological Databases and Curation
Jinding LiuShuiqing Huang

Abstract

Frequent A-to-I RNA editing has recently been identified in fungi despite the absence of recognizable homologues of metazoan ADARs ("Adenosine Deaminases Acting on RNA"). In particular, there is emerging evidence showing that A-to-I editing is involved in sexual reproduction of filamentous fungi. Here, we report on the creation of FairBase - a fungal A-to-I RNA editing database that provides a platform for deep exploration of fungal RNA editing to relevant academic communities. This database includes a comprehensive collection of A-to-I editing sites in six filamentous fungal species, together with extensive annotations for each editing site. In FairBase, users can conveniently search editing sites and obtain editing levels for each editing site in various RNA-seq samples. In addition, the pathways involving RNA editing are built in FairBase to help users understand the functions of RNA editing. Furthermore, each fungal species has a genome browser (JBrowse) that allows users to explore A-to-I editing in a genomic context. FairBase is the first fungal RNA editing database.

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Citations

May 10, 2020·Applied Microbiology and Biotechnology·Ines Teichert
Jul 8, 2020·International Journal of Molecular Sciences·Julia MathlinTeresa Colombo

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Methods Mentioned

BETA
RNA-seq
deamination
whole genome shotgun sequencing

Software Mentioned

Hisat2
Trimmomatic
JavaScript
RADAR
FairBase
REDItool
Ensembl
REDIportal
JBrowse browser
InterProScan

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