Abstract
Integrins function to bind cells to extracellular matrix in tissues, which triggers downstream signaling cascades that are important in cell survival, proliferation, cytokine activation, and cytoskeleton reorganization. These processes also play significant roles in neoplasms. This work aimed to investigate the pattern of expression of FAK, paxillin, and PI3K in ameloblastoma and adenomatoid odontogenic tumor (AOT). Immunohistochemistry was used to study FAK, paxillin, and PI3K in 45 ameloblastomas (32 conventional, 12 unicystic, and 1 peripheral types), 7 AOTs, and two developing human teeth. Weak expression of FAK was seen in all AOT cases, while ameloblastoma had varying expression patterns, mostly strong to weak. The pattern of expression of paxillin and PI3K was relatively similar in both tumor types. In the dental germ, FAK and paxillin stained all the enamel organ components, while PI3K stained strongly the inner enamel epithelium. Stromal expression of FAK was not found to be useful in differentiating between tumors or tumor classes. The expression of the proteins in the enamel organ suggests that their signaling may be important in odontogenesis. While some ameloblastomas strongly expressed FAK, all cases of AOT had we...Continue Reading
References
Mar 27, 1996·Biochimica Et Biophysica Acta·C BachelotL C Cantley
Oct 3, 1998·The Journal of Biological Chemistry·H FujitaK Tachibana
Aug 9, 2001·Histopathology·Y SoiniV Kinnula
Mar 19, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Tsutomu YuminamochiYukio Ozaki
Apr 18, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Steven K HanksJan Brábek
Jan 27, 2004·Nature Cell Biology·Donna J WebbAlan F Horwitz
Aug 3, 2005·Nature Reviews. Cancer·Gordon W McLeanMargaret C Frame
Feb 16, 2006·Oral Diseases·H Kumamoto, K Ooya
Jul 11, 2006·Molecular Pharmacology·Maroesja J van NimwegenBob van de Water
Dec 22, 2006·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Ibrahim O BelloTuula Salo
Feb 27, 2007·The Breast Journal·Sarah M ShortDavid G Hicks
Jun 25, 2008·International Journal of Surgical Pathology·Emanuel Sávio de Souza AndradeLélia Batista de Souza
Dec 17, 2009·Expert Opinion on Therapeutic Targets·Christopher A Lipinski, Joseph C Loftus
Dec 1, 2005·Journal of Applied Oral Science : Revista FOB·Marcelo Macedo CriveliniRenata Callestini Felipini
Nov 4, 2010·Journal of Clinical Pathology·Alexander C MackinnonRavi Salgia
Dec 17, 2010·Cancer Research·De-Wei WuHuei Lee
Feb 2, 2011·Journal of Dental Research·P DeVilliersJ T Wright
Dec 3, 2011·The Journal of Biological Chemistry·Asha EapenAnne George
Dec 12, 2012·Genes & Cancer·Nicholas O DeakinChristopher E Turner
Sep 12, 2013·Biochemical and Biophysical Research Communications·Sundaralingam PremarajThyagaseely Premaraj
Jan 1, 2014·The Journal of Pathology·Kari J KurppaKristiina Heikinheimo
Mar 20, 2014·PloS One·Thérèse B DeramaudtPhilippe Rondé
Mar 17, 2016·Oncotarget·Rajani KantetiRavi Salgia
Sep 15, 2016·Oncotarget·Romana MoenchMartin Gasser
Nov 24, 2016·Medical Hypotheses·Arush ThakurAmrut V Hanchate
Dec 10, 2016·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Sachin C SarodeShankargouda Patil
Mar 2, 2017·Head and Neck Pathology·John M Wright, Marilena Vered
Jul 5, 2017·Medical Hypotheses·Fumio IdeKaoru Kusama
Sep 27, 2018·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Bruno Ramos Chrcanovic, Ricardo Santiago Gomez
Jan 8, 2019·Oral Diseases·Faqi Nurdiansyah HendraHenrica C W de Vet
Jan 16, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Bruna Pizziolo CouraCarolina Cavalieri Gomes
Nov 19, 2019·Dental Clinics of North America·Arvind Babu Rajendra Santosh, Orrett E Ogle