Falciparum malaria in malaria-naive travellers and African visitors

QJM : Monthly Journal of the Association of Physicians
A BunnJ F Doherty

Abstract

Patients from malaria-endemic areas who present in non-endemic countries with Plasmodium falciparum malaria are often assumed to have some degree of immunity. If this were reliably true, it would simplify their management. To determine whether being born and resident in a malaria-endemic country is a predictor of clinical course in UK admissions for malaria. Prospective observational study. We compared clinical and laboratory parameters between two groups of adult patients with acute P. falciparum malaria, admitted to the Hospital for Tropical Diseases in London: one born and resident in non-endemic countries (n=167); the other born and resident in malaria-endemic countries of Africa (n=93). Patients were excluded if they had taken prophylaxis or prior treatment. There were no differences between these two groups in terms of peak parasitaemia or time to parasite clearance. There was a significantly higher risk of malaria-naive patients having peak parasitaemia >5% (OR 4.5, 95%CI 1.5-13.2). Of those usually resident in Africa, 31% required parenteral treatment compared to 41% of the malaria-naive group. Of the visitors from Africa, 4.3% needed admission to the Intensive Therapy Unit (ITU), although there was a tendency for more ...Continue Reading

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Citations

Feb 2, 2006·Current Infectious Disease Reports·Alan J Magill
Jan 13, 2009·Clinical Microbiology Reviews·Denise L DoolanJ Kevin Baird
Jul 5, 2008·BMJ : British Medical Journal·Adrian D SmithChristopher J M Whitty
Mar 29, 2012·BMJ : British Medical Journal·Anna M CheckleyChristopher J M Whitty
Jul 1, 2008·QJM : Monthly Journal of the Association of Physicians·C Nic FhogartaighC J M Whitty
Jul 27, 2007·Scandinavian Journal of Infectious Diseases·Ida E GjørupIb C Bygbjerg
Feb 18, 2016·The Journal of Infection·David G LallooUNKNOWN PHE Advisory Committee on Malaria Prevention in UK Travellers
Sep 22, 2007·Journal of Travel Medicine·Valérie BriandArnaud Fontanet
Jan 12, 2007·The Journal of Infection·David G LallooUNKNOWN HPA Advisory Committee on Malaria Prevention in UK Travellers
May 31, 2015·QJM : Monthly Journal of the Association of Physicians·H SharmaJ L Klein
Aug 6, 2015·PLoS Neglected Tropical Diseases·Monica L Rojas-PeñaMyriam Arévalo-Herrera
Mar 13, 2020·Clinical Microbiology Reviews·Johannes MischlingerMichael Ramharter
Jul 6, 2005·Journal of Travel Medicine·Pietro CaramelloGiovanni Di Perri

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