Faldaprevir for the treatment of hepatitis C

International Journal of Molecular Sciences
Tatsuo KandaMasao Omata

Abstract

The current treatments for chronic hepatitis C virus (HCV) genotype 1 infection are combinations of direct-acting antivirals, and faldaprevir is one of the new generation of HCV NS3/4A protease inhibitors. At the end of 2013, the US Food and Drug Administration (FDA) approved the HCV NS3/4A protease inhibitor simeprevir and the HCV NS5B polymerase inhibitor sofosbuvir. Simeprevir or sofosbuvir in combination with pegylated interferon and ribavirin are available for clinical use. Faldaprevir, another HCV NS3/4A protease inhibitor that also has fewer adverse events than telaprevir or boceprevir, is under development. Of interest, faldaprevir in combination with pegylated interferon and ribavirin, and interferon-free treatment with faldaprevir in combination with deleobuvir plus ribavirin provides high sustained virological response rates for HCV genotype 1 infection. The aim of this article is to review these data concerning faldaprevir. Faldaprevir in combination with pegylated interferon and ribavirin treatment appears to be associated with fewer adverse events than telaprevir or boceprevir in combination with pegylated interferon and ribavirin, and may be one of the therapeutic options for treatment-naive patients with HCV gen...Continue Reading

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Citations

Jan 10, 2018·World Journal of Hepatology·Reza Taherkhani, Fatemeh Farshadpour
Jan 2, 2018·World Journal of Gastroenterology : WJG·Tatsuo KandaMitsuhiko Moriyama
Jan 5, 2021·Frontiers in Pharmacology·Bruno Silva AndradeVasco Ariston de Carvalho Azevedo
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gita MatulevičiūtėAlgirdas Šačkus

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