Falls and Fall-Prevention in Older Persons: Geriatrics Meets Spaceflight!

Frontiers in Physiology
Nandu Goswami

Abstract

This paper provides a general overview of key physiological consequences of microgravity experienced during spaceflight and of important parallels and connections to the physiology of aging. Microgravity during spaceflight influences cardiovascular function, cerebral autoregulation, musculoskeletal, and sensorimotor system performance. A great deal of research has been carried out to understand these influences and to provide countermeasures to reduce the observed negative consequences of microgravity on physiological function. Such research can inform and be informed by research related to physiological changes and the deterioration of physiological function due to aging. For example, head-down bedrest is used as a model to study effects of spaceflight deconditioning due to reduced gravity. As hospitalized older persons spend up to 80% of their time in bed, the deconditioning effects of bedrest confinement on physiological functions and parallels with spaceflight deconditioning can be exploited to understand and combat both variations of deconditioning. Deconditioning due to bed confinement in older persons can contribute to a downward spiral of increasing frailty, orthostatic intolerance, falls, and fall-related injury. As as...Continue Reading

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Citations

Nov 23, 2017·Frontiers in Physiology·Nandu GoswamiJean-Pierre Montani
Dec 13, 2018·Physiological Reviews·Nandu GoswamiVictor A Convertino
Feb 13, 2020·International Journal of Environmental Research and Public Health·M H MahbubTsuyoshi Tanabe
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Aug 6, 2019·Frontiers in Physiology·Ajay K VermaKouhyar Tavakolian
Sep 3, 2020·International Journal of Environmental Research and Public Health·Ellen BentlageMichael Brach
Mar 15, 2019·Zeitschrift für Gerontologie und Geriatrie·Irhad TrozicNandu Goswami
Apr 5, 2018·Frontiers in Physiology·Yunfang GaoNandu Goswami
Feb 13, 2019·Frontiers in Physiology·Olivier WhiteNandu Goswami
Nov 20, 2020·Journal of Clinical Medicine·Bianca BrixNandu Goswami
Jan 31, 2021·Scientific Reports·Michihiko ShimomuraDai Shiba
Nov 19, 2020·Clinical Interventions in Aging·Nandu GoswamiDaniel Cardinali
Apr 4, 2021·Biology·Bianca BrixNandu Goswami
May 1, 2021·Biology·Sebastian Lucio FilelfiNandu Goswami
May 29, 2021·Frontiers in Physiology·Chrysoula Kourtidou-PapadeliJoan Vernikos
Aug 8, 2021·Journal of Clinical Medicine·Anna Kabata-PiżuchAnna Marchewka

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