False-positive Aspergillus galactomannan and its kinetics in allogeneic hematopoietic stem cell transplantation

The Journal of Infection
Shun-Ichi KimuraYoshinobu Kanda

Abstract

We evaluated the incidence of and risk factors for false-positive Aspergillus galactomannan (GM) antigenemia in allogeneic hematopoietic stem cell transplantation (HSCT). We also focused on the GM index value and its kinetics. Patients who underwent their first allogeneic HSCT at our center between June 2007 and December 2012 were included (n = 172). Episodes of positive GM tests were classified as either "true-positive", which fulfilled the EORTC criteria for proven or probable invasive aspergillosis (IA), or "false-positive", which was not accompanied by clinical findings. The remaining cases were regarded as "inconclusive". The one-year cumulative incidences of IA and positive GM tests were 10.1% and 48.1%, respectively. Among 148 episodes of positive GM tests, 97(65.5%), 23(15.5%), and 28(19.0%) were classified as false-positive, true-positive and inconclusive, respectively. In the first episodes of positive GM tests in each patient (false-positive = 67, others = 30), an increase in the GM value in the first two measurements, neutropenia, and use of anti-mold agents at positive GM episode were associated with a significantly lower possibility of false-positive results according to a multivariate analysis. A false-positive G...Continue Reading

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Citations

Jun 3, 2016·Medical Mycology Journal·Shun-Ichi Kimura
Jun 28, 2016·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Ugur SahinTaner Demirer
Nov 7, 2016·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Gulhadiye AvcuYesim Aydinok
Jun 24, 2016·Microbiology Spectrum·Andrea J ZimmerKaren C Bloch

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