False-positive ethylene glycol levels in patients with diabetic ketoacidosis.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
C MartinezF Kayne

Abstract

To describe two patients with diabetic ketoacidosis and positive ethylene glycol levels and to call attention to the possibility of a false-positive ethylene glycol determination in patients with ketoacidosis. Clinical manifestations and laboratory tests in the two patients were summarized. Serum specimens for both patients were analyzed for ethylene glycol, serum ketones, glucose, osmolality, pH, and electrolytes. Respective laboratory findings in our two patients were as follows: serum glucose levels, 56.4 and 45.7 mmol/L; serum acetone, positive in 1:80 and 1:128 dilution; serum osmolality, 366 and 377 mmol/kg; pH, 6.9 and 7.2; and ethylene glycol, 3.46 and 2.45 mmol/L. Neither of these two elderly women had ingested ethylene glycol; nevertheless, both had positive results for ethylene glycol on a blood toxicology screen. Review of the literature demonstrates that false-positive ethylene glycol levels can be detected in patients with ketoacidosis. This information is documented in this report and should alert practicing physicians to such a possibility.

References

Jul 1, 1988·The Journal of Emergency Medicine·M C HauptS L Adams
Jan 1, 1994·Journal of Toxicology. Clinical Toxicology·P BjellerupM Kollind

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Citations

Jan 25, 2012·Journal of Forensic Sciences·Thomas H PetersenRichard Harruff
Nov 17, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·William H Porter
Nov 30, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Jeffrey A Kraut, Ira Kurtz
Feb 2, 2010·Advanced Emergency Nursing Journal·Deanna M McMahonKyle A Weant
Apr 1, 2011·NDT Plus·Riaz V BavakunjiNicholas M Selby

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