False-positive Histoplasma antigenemia caused by antithymocyte globulin antibodies

Transplant Infectious Disease : an Official Journal of the Transplantation Society
L Joseph WheatM D Pescovitz

Abstract

False-positive Histoplasma antigen results were identified in two patients who received rabbit antithymocyte globulin (ATG, Thymoglobulin(R)) to prevent allograft rejection. To determine the prevalence of false-positive results following the administration of Thymoglobulin, sequential specimens were tested from a cohort of transplant recipients. Of 107 such patients, 17 (15.9%) demonstrated false-positive tests for Histoplasma antigenemia. False antigenemia peaked at 2-4 weeks after ATG administration and cleared over the next few months. Physicians should be aware of the potential for false-positive results in specimens from patients who have received ATG.

Citations

Nov 15, 2007·Current Infectious Disease Reports·L Joseph Wheat
Mar 17, 2007·Medical Mycology·L Joseph WheatPatricia Connolly
May 19, 2007·Medical Mycology·Fernanda P Silveira, Shahid Husain
Mar 1, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L J WheatE Jenny-Avital
Feb 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tim KuberskiDavid Pegues
Jan 19, 2008·Clinical Microbiology Reviews·P Martín-DávilaS Moreno
Jan 16, 2007·Clinical Microbiology Reviews·Carol A Kauffman
Oct 20, 2006·Expert Opinion on Biological Therapy·L Joseph Wheat
Aug 18, 2006·Transplant Infectious Disease : an Official Journal of the Transplantation Society·L J Wheat
Nov 23, 2006·Transplant Infectious Disease : an Official Journal of the Transplantation Society·L J WheatM D Pescovitz
May 9, 2018·Current Opinion in Infectious Diseases·Kiran GajurelStan Deresinski
Mar 10, 2017·Journal of Clinical Microbiology·Marwan M Azar, Chadi A Hage
Jul 3, 2008·Current Opinion in Infectious Diseases·Carol A Kauffman
Apr 13, 2007·Clinical and Vaccine Immunology : CVI·Mark D LindsleyChristine J Morrison
Oct 5, 2007·Clinical and Vaccine Immunology : CVI·Patricia A ConnollyL Joseph Wheat
May 9, 2019·Open Forum Infectious Diseases·Amrit KaurKiran Gajurel
Dec 22, 2019·Journal of Fungi·Izadora Clezar da Silva VasconcellosAlessandro C Pasqualotto
Feb 16, 2021·Applied Microbiology and Biotechnology·María Agustina ToscaniniMaría Luján Cuestas
Oct 10, 2007·Clinical and Vaccine Immunology : CVI·L Joseph Wheat
Oct 10, 2007·Clinical and Vaccine Immunology : CVI·Joann L CloudEdward R Ashwood

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