False-positive serum prostate-specific antigen values in a patient with non-Hodgkin lymphoma of the kidney

Urology
B DjavanC G Roehrborn

Abstract

Prostate-specific antigen (PSA) is the clinically most useful tumor marker for prostate cancer. Although false-positive elevations have been reported due to disease processes outside the prostate gland with the use of the polyclonal assay, such false-positive test results have been exceedingly rare with the use of the monoclonal assay. We report the case of a patient diagnosed with a B-cell lymphoma of the kidney and a significant elevation of serum PSA levels by monoclonal assay in the absence of either inflammatory or malignant prostate disease. PSA returned to normal during lymphoma-specific chemotherapy with a cyclophosphamide, mechlorethamine, vincristine, procarbazine, prednisone regimen. Possible explanations and clinical implications are discussed.

Citations

Jun 1, 1997·The Prostate·X GaoK V Honn
Nov 15, 1996·International Journal of Cancer. Journal International Du Cancer·X FilellaA M Ballesta
Nov 26, 1999·Breast Cancer Research and Treatment·K A AlanenT J Nevalainen
Sep 7, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Jaume TrapéUNKNOWN Oncology Section of the Catalan Association of Clinical Laboratory Science
Jul 20, 2007·European Journal of Haematology·Jan Jelrik OosterheertShulamiet Wittebol
Sep 25, 1997·The Journal of Urology·M K TerrisF S Freiha

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