False-positive urine opiate screening associated with fluoroquinolone use

The Annals of Pharmacotherapy
Jennifer L Zacher, Donna M Givone

Abstract

To review the literature regarding false-positive urine opiate screens associated with the use of fluoroquinolones. Literature was identified using MEDLINE (1966-February 2004), EMBASE, and all EBM Reviews with the terms quinolones, substance abuse detection, opiates, cross-reactions, false-positive reactions, and each fluoroquinolone. Article references were also reviewed. Various settings utilize the practice of screening for drugs of abuse, such as opiates. These screening procedures can impact aspects of one's life, such as employment; therefore, accuracy is of the utmost importance. Two clinical trials were evaluated which showed that certain fluoroquinolone antibiotics cross-react with some of the commonly used urine opiate screening immunoassays. This suggests the importance of verifying positive results in instances where one's livelihood can be affected. Fluoroquinolones can cause false-positive urine opiate screens. Clinicians should be aware of this potential interaction and may need to verify positive results.

References

Feb 1, 1997·Therapeutic Drug Monitoring·R Meatherall, J Dai
Jun 25, 1998·Clinical Chemistry and Laboratory Medicine : CCLM·M de PaulaE Miravalles
Nov 4, 1998·Forensic Science International : Synergy·C MeadwayR Braithwaite
Apr 27, 1999·Therapeutic Drug Monitoring·B KapurV Gaughan
Oct 12, 1999·Journal of Analytical Toxicology·A D Fraser, D Worth
Jan 5, 2002·JAMA : the Journal of the American Medical Association·L R BadenG M Eliopoulos

❮ Previous
Next ❯

Citations

Apr 4, 2009·Clinical Chemistry·Matthew D KrasowskiSean Ekins
Sep 30, 2010·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Qaiser Shafiq, Anand Mutgi
Oct 7, 2010·Journal of Addictive Diseases·Peter L Tenore
Jun 10, 2010·AIDS and Behavior·Katherine TassiopoulosGeorge R Seage
Jul 1, 2008·General Hospital Psychiatry·Boonsong KiangkitiwanBrian Bohner
Mar 1, 2006·Pharmacotherapy·Craig M StraleyMark P Herriman
Sep 15, 2011·Drug Testing and Analysis·Christine Moore
Jun 5, 2012·Annales pharmaceutiques françaises·P MuraJ-P Goullé
Apr 22, 2011·Journal of Pharmacy Practice·Charles HerringCynthia Johnston
Aug 7, 2010·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Nancy C BrahmTony A Palmer
Oct 13, 2019·The Oncologist·Joseph A Arthur
Feb 12, 2020·The Oncologist·Joseph A Arthur
Apr 1, 2015·Pediatrics·Sharon LevyUNKNOWN Committee on Substance Abuse, American Academy of Pediatrics

❮ Previous
Next ❯

Methods Mentioned

BETA
fluorescence polarization immunoassay

Software Mentioned

Abuscreen
Abuscreen OnLine
EMIT
CEDIA

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.