Famciclovir therapy for recurrent hepatitis B virus infection after liver transplantation

Transplant International : Official Journal of the European Society for Organ Transplantation
G W HallerP Neuhaus

Abstract

Between November 1993 and June 1995 18 patients received oral famciclovir (3 x 500 mg) for treatment of hepatitis B virus (HBV) reinfection after liver transplantation. Reinfection was defined as the reoccurrence of HBsAg in the serum. In the first 15 patients, famciclovir therapy was initiated after clinical signs of graft hepatitis, whereas the last 3 patients received treatment immediately after HBV-DNA was detected. Famciclovir was well-tolerated in all patients. HBV-DNA values were decreased to undetectable levels in 8 out of 18 patients. Clinical status improved in 7 patients, whereas 5 patients remained unchanged and 6 patients progressed to deteriorating graft function and death. When famciclovir was initiated early after reinfection, a response rate of approximately 66% was observed. Late onset of therapy in patients with fulminant hepatitis generally failed to provide any clinical benefit.

Citations

Jul 1, 1995·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·E R Schiff
Sep 12, 2000·Current Gastroenterology Reports·F Yao, R G Gish
Mar 12, 1999·The Surgical Clinics of North America·S F DodsonA Bonham
Jun 26, 1999·Journal of Gastroenterology and Hepatology·N H Bzowej, T L Wright
Jun 25, 1998·American Journal of Respiratory and Critical Care Medicine·H ShennibA Giaid
Nov 20, 1998·The American Journal of Gastroenterology·S H HanR W Busuttil
Mar 10, 2001·The American Journal of Gastroenterology·M BerenguerJ Berenguer
Apr 23, 2002·Clinical Transplantation·Ulf P NeumannPeter Neuhaus

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