PMID: 11336847May 5, 2001Paper

Familial abdominal aortic aneurysms in the Otago region of New Zealand

Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery
J I RossaakA M van Rij

Abstract

To investigate the familial incidence and phenotypic characteristics of patients with abdominal aortic aneurysms (AAA) in the Otago region of New Zealand. A retrospective audit based pilot study and a prospective study of patients having abdominal aortic aneurysm repair from September 1988 to September 1999 was performed. 248 probands were enrolled, of which 19.4% had one or more first degree relative affected. The age at diagnosis of the familial (70.2) and non-familial (70.5) patients was similar. The proportion of females was increased in the familial subgroup. Hypercholesterolaemia was the only phenotypic feature to differentiate familial from non-familial patients and was associated with an earlier age of presentation. In the familial families, brothers were the most common relative affected and 77% of the families had two patients with AAA. 19.4% of patients operated on in the Otago area for AAA had a familial component to their aneurysm.

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Citations

Oct 26, 2005·Annals of Surgery·Claire Le HelloUNKNOWN Association Universitaire pour la Recherche en Chirurgie
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