PMID: 3919066Mar 1, 1985

Familial abnormalities of thyroxine binding proteins: some problems of recognition and interpretation

Journal of Clinical Pathology
J E NeildB M Slavin

Abstract

A three generation family study was carried out after inappropriate treatment with radioactive iodine of a 50 year old woman with a raised serum total thyroxine concentration and free thyroxine index. Subsequent investigations showed that she and five members of her family had raised thyroxine binding globulin concentrations. Free thyroxine and free triiodothyronine concentrations were normal. Problems encountered in the recognition of this thyroxine binding protein disorder are discussed. Clinicians and clinical biochemists should be aware of these pitfalls and thus avoid further incorrect treatment on the basis of biochemical findings, even though free hormone estimations are now becoming readily available.

References

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Citations

Aug 1, 1994·Acta Paediatrica Japonica; Overseas Edition·A NakaiM Sudo
Jan 1, 1995·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·A E HeufelderH Gharib
Mar 15, 2021·Mayo Clinic Proceedings·Paolo B DominelliMichael J Joyner

Related Concepts

Blood Protein Disorders
Genealogical Tree
Prealbumin
Novothyral
Thyroxine-Binding Proteins
Cytomel
Reverse Triiodothyronine

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