Familial aggregation and coaggregation of history of hypertension and stroke

Journal of Human Hypertension
T KondoJACC Study Group

Abstract

We attempted to evaluate familial aggregation and coaggregation of history of hypertension and stroke. Past and family history of hypertension and stroke for 83 089 probands and their relatives were obtained from a data set for the Japan Collaborative Cohort Study for Evaluation of Cancer Risk sponsored by the Ministry of Education (JACC Study), which was initiated from 1988 to 1990. First, evaluation was performed for familial aggregation of each of two disorders using ordinal logistic regression of the generalized estimation equations (GEE) to account for dependence of observations within families. Secondly, in order to evaluate the familial congregation of the history of hypertension and stroke, a GEE-based multivariate probed predictive model was applied. After adjusting for the proband's age, level of obesity, smoking status, drinking status, habitation area, and the gender and type of the relatives, the estimated odds ratios for the intraindividual clustering and familial aggregation of the disease history showed statistically significant relationships. In addition, the history of the two disorders showed a significant relationship in terms of familial coaggregation independently of the aggregation of each disorder itself...Continue Reading

References

Jul 1, 1984·American Journal of Epidemiology·I M LonginiJ B Keller
Sep 1, 1993·Stroke; a Journal of Cerebral Circulation·D K KielyR H Myers
Feb 5, 2000·Stroke; a Journal of Cerebral Circulation·M NicolaouL A Farrer
Aug 5, 2000·Journal of Human Hypertension·R M FuentesA Nissinen
Aug 22, 2001·Journal of Epidemiology·Y OhnoUNKNOWN JACC Study Group

❮ Previous
Next ❯

Citations

Feb 8, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Afsana MomenLawrence I Sinoway
Jun 7, 2008·Neuroepidemiology·Lynda D LisabethLewis B Morgenstern
Oct 31, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Aya KadotaUNKNOWN NIPPON DATA80 Research Group
Dec 17, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Ambar KulshreshthaSuzanne E Judd
Nov 4, 2006·Stroke; a Journal of Cerebral Circulation·Marie Josee E van RijnMonique M B Breteler
Sep 3, 2019·Journal of Alzheimer's Disease : JAD·Ambar KulshreshthaViola Vaccarino
Oct 27, 2018·Current Hypertension Reports·Ștefania MateiBogdan Dorobanțu
Mar 16, 2021·Acta Diabetologica·Anni YlinenUNKNOWN FinnDiane Study Group
Sep 1, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Michał BłażAnetta Undas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.