Familial aggregation in atypical Parkinson's disease: a case control study in multiple system atrophy and progressive supranuclear palsy.

Journal of Neurology
Jean-Sébastien VidalAnnick Alpérovitch

Abstract

Familial aggregation has been consistently found in PD, but it is unclear whether there is a familial aggregation in families of patients with multiple system atrophy (MSA) or progressive supranuclear palsy (PSP). MSA and PSP cases were recruited from a two-arm case control study. One control was matched to each case for age, gender and living area. Medical history of first-degree relatives was obtained through a face-to-face questionnaire. Age-specific cumulative incidence of Parkinsonism and dementia in first-degree relatives of cases and controls was compared for MSA and PSP separately. Seventy-one pairs for MSA and their controls and 79 pairs for PSP and their controls were included. No significant familial aggregation was found in PSP. MSA cases reported Parkinsonism more often, but not dementia in their first-degree relatives than controls. MSA patients, but not those with PSP, have Parkinsonism more often in their first-degree relatives than controls.

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Citations

Oct 27, 2015·International Journal of Molecular Sciences·Sonja W Scholz, Jose Bras
Feb 11, 2015·Journal of Neurology·Han-Joon KimKurt A Jellinger
Feb 18, 2015·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Monica FederoffAndrew Singleton
Oct 7, 2017·Journal of Alzheimer's Disease : JAD·Kurt A Jellinger
Oct 13, 2017·Expert Review of Neurotherapeutics·Kurt A Jellinger
May 18, 2011·Current Opinion in Neurology·Gregor K WenningWerner Poewe
Apr 25, 2015·Annals of Clinical and Translational Neurology·Jun MitsuiShoji Tsuji
Apr 13, 2018·Journal of Neural Transmission·Michitaka MikasaNobutaka Hattori
Nov 15, 2011·Neuropathology and Applied Neurobiology·Z AhmedJ L Holton
Jan 9, 2014·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Kyoko ItohShinji Fushiki
Oct 7, 2021·Journal of Neural Transmission·David J MarmionJeffrey H Kordower

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