PMID: 18408421Apr 15, 2008Paper

Familial aggregation of gastric cancer

Gan to kagaku ryoho. Cancer & chemotherapy
Haruhiko Sugimura

Abstract

Pursuit of the etiologies of familial aggregation of gastric cancer is a particular challenge in an endemic area like Japan. A typical case having truncation-type CDH1 germline mutation, which constitutes an entity of hereditary diffuse gastric cancer, has never been found in Japan or Korea. In addition to candidate gene approaches, painstaking efforts are now in progress using several genome-wide approaches including genome-wide association studies which require a few replications of several thousands of cases and controls. Gene-environmental interactions are also determined to find out the attributes for gastric cancer predisposition.

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Related Papers

JAMA : the Journal of the American Medical Association
P KaurahD Huntsman
European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
S R GhaffariJ Dastan
European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
C J MoranO J McAnena
© 2022 Meta ULC. All rights reserved