Familial aggregation of major depressive disorder in an African-American community

Depression and Anxiety
Eleanor MurphyRuth Ottman

Abstract

African Americans (AAs) with major depressive disorder (MDD) experience more impairment and poorer treatment outcomes relative to Whites, yet are underrepresented in family studies of MDD. This is the first study to investigate the familial aggregation of major depression among AAs. Participants' reports of depression from clinical and family history (FH) interviews were used to examine depression rates among 435 first-degree relatives and half-siblings of 63 depressed cases and 222 relatives of 33 nondepressed controls. Binary logistic regression was used to compute odds ratios (ORs) for FH of MDD and level of trauma exposure (high and low) in cases versus controls. Poisson regression models with generalized estimating equations were used to assess MDD in relatives of cases versus relatives of controls. Cases and controls did not differ in either FH of MDD (OR = 1.2, 95% confidence interval [CI] = 0.5-2.9), or prevalence of MDD in relatives (relative risk [RR] = 1.5, 95% CI = 0.8-2.5). However, exposure to high trauma was associated with increased risk of MDD (OR = 3.0, 95% CI = 1.22-7.17) and the combined effect of FH and trauma was greater than expected under an additive model. Similarly, the RR for MDD among relatives of ca...Continue Reading

References

Apr 1, 1992·Journal of Psychiatric Research·T A KostenB J Rounsaville
Aug 11, 1992·Archives of General Psychiatry·J B WilliamsB Rounsaville
Sep 1, 1989·Journal of Affective Disorders·D J KupferK Neiswanger
Jan 1, 1989·American Journal of Epidemiology·E Susser, M Susser
Dec 1, 1984·Archives of General Psychiatry·M M WeissmanG D Gammon
Oct 1, 1982·Archives of General Psychiatry·E S GershonW E Bunney
Nov 1, 1996·Preventive Medicine·R Ottman
May 22, 1998·Archives of General Psychiatry·M J LyonsM T Tsuang
Jan 19, 1999·Archives of General Psychiatry·K S Kendler, C A Prescott
Jul 13, 2000·Archives of General Psychiatry·M M WeissmanM Olfson
Sep 29, 2000·The American Journal of Psychiatry·P F SullivanK S Kendler
Mar 8, 2002·European Archives of Psychiatry and Clinical Neuroscience·U PtokR Heun
May 17, 2003·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Francis E LotrichRobert E Ferrell
Mar 23, 2004·American Journal of Epidemiology·Guangyong Zou
Oct 16, 2004·Assessment·Matt J GrayThomas W Lombardo
Aug 25, 2007·Annual Review of Clinical Psychology·Constance Hammen
Aug 30, 2007·International Journal of Epidemiology·Mirjam J KnolMirjam I Geerlings
Feb 6, 2008·Archives of General Psychiatry·Rebekah G BradleyKerry J Ressler
Mar 1, 2008·Journal of Psychopharmacology·Ib ChaudhryN Husain
May 2, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·B J MilneT E Moffitt
Feb 5, 2009·Kidney International·Renée de MutsertFriedo W Dekker
Dec 30, 2009·Genetic Epidemiology·Tyler J VanderWeeleMiguel A Hernán
Feb 19, 2010·Addictive Behaviors·Gregory G HomishKenneth E Leonard
Aug 12, 2010·The Journal of Nervous and Mental Disease·Anu AsnaaniStefan G Hofmann
Sep 14, 2011·Annals of Family Medicine·Robert A BellRichard L Kravitz
Jul 1, 1997·Journal of Health Psychology·D R WilliamsN B Anderson
Jan 19, 2012·International Journal of Epidemiology·Mirjam J Knol, Tyler J VanderWeele
Feb 28, 2013·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Torsten Klengel, Elisabeth B Binder
Aug 10, 2013·American Journal of Public Health·Joan Y Chiao, Katherine D Blizinsky
Aug 27, 2017·Journal of Racial and Ethnic Health Disparities·Shervin Assari, Cleopatra H Caldwell

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