Familial aggregation of oesophageal cancer in a high incidence area in China

International Journal of Epidemiology
J Chang-ClaudeJ Wahrendorf

Abstract

The high incidence of oesophageal cancer in northern China is attributed predominantly to environmental factors. The role of genetic factors has not been extensively studied. Our aim was to study familial aggregation of oesophageal cancer in pedigrees from a defined population base in a high incidence area in China and to quantify the risk associated with different first degree relatives using different analytical approaches. Detailed data on family members of three successive generations and the occurrence of oesophageal and other cancers in family members were collected from a population-based series of 244 oesophageal cancer cases which occurred between 1987 and mid-1992 in Huixian County, Henan. Compared to expected rates, the standardized mortality ratio (SMR) of oesophageal cancer among first degree relatives of oesophageal cancer patients was 2.4 (2.2 in male and 2.7 in female relatives). The corresponding SMR for first and second degree relatives were 1.6 and 2.2. The null hypothesis of 'no familial aggregation' was rejected using Tarone's one-sided score test for binomial distributions indicating some evidence for clustering within families. To account for variance due to between-pairs correlation and family and/or ind...Continue Reading

Citations

Oct 16, 1999·International Journal of Cancer. Journal International Du Cancer·Y YokokawaT Nakajima
Feb 22, 2002·International Journal of Cancer. Journal International Du Cancer·Kari Hemminki, Yongwen Jiang
Jun 8, 2001·International Journal of Cancer. Journal International Du Cancer·P K DhillonJ F Fraumeni
Sep 30, 2004·International Journal of Cancer. Journal International Du Cancer·Gina D TranPhilip R Taylor
Aug 6, 2008·Nature Clinical Practice. Gastroenterology & Hepatology
Feb 3, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Rumaisa RafiqNazir Ahmad Dar
Oct 3, 2012·The Surgical Clinics of North America·Jason B Wheeler, Carolyn E Reed
May 9, 2012·Journal of Proteomics·Yi-Jun QiJen-Fu Chiu
Mar 31, 2009·Gastroenterology Clinics of North America·Yutaka Tomizawa, Kenneth K Wang
Apr 27, 2012·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·W WeiL D Wang
Nov 21, 2012·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Y-J MiY-Q Chen
Apr 28, 2009·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Sheng-Ping HuKe-Li Cai
May 9, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Jianguang Ji, Kari Hemminki
Apr 30, 2015·International Journal of Epidemiology·Hyuna SungPaula L Hyland
Apr 12, 2016·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Y QuL Dai
Apr 17, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jinhan WangNaiyao Chen
Dec 3, 2014·International Journal of Hygiene and Environmental Health·W R TangW W Au
May 18, 2001·Best Practice & Research. Clinical Gastroenterology·H Messmann
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Huiying ZhiZhihua Liu
Nov 18, 2005·European Journal of Gastroenterology & Hepatology·Jian-Ming WangQing-Wu Jiang
Mar 30, 2006·International Journal of Cancer. Journal International Du Cancer·Mohammad Reza AkbariSteven A Narod
Jul 11, 2003·World Journal of Gastroenterology : WJG·Jian-Hui ZhangShi-Jie Wang
Jul 18, 2015·Journal of Gastroenterology and Hepatology·Denggui WenBaoen Shan
May 12, 2019·Journal of Translational Medicine·Doris KlingelhöferDavid A Groneberg
Jul 6, 2010·International Journal of Cancer. Journal International Du Cancer·Ming WuJin-Kou Zhao
Mar 15, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Liyong ZhangZhihua Liu
Mar 4, 2021·Southern Medical Journal·Michael DiSienaHouman Rezaizadeh

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