Familial aggregation of skin sensitization to aeroallergens in a rural area in China

International Archives of Allergy and Immunology
Yongtang JinSaoli Xue

Abstract

The prevalence of allergic sensitization has increased all over the world during last years and allergic sensitization may be related to genetic or environmental factors or to both. The objective of this study was to estimate the prevalence rates of allergic sensitization and assess the familial aggregation of allergic sensitization to aeroallergens in asthma index families. The skin prick test (SPT) reactivity to 8 aeroallergens and the SPT reactivity-related risk factors were evaluated. The allergic sensitization was based on SPT. Univariate and multivariate logistic regressive models were used to estimate the effect size (odds ratio, OR) of correlation within families with positive SPT. Of 4,213 analyzed subjects in 1,006 asthma index families, 40.9% had at least one positive SPT, 42.3% in parents (father: 43.3%; mother: 42.3%), 43.9% in first offspring, and 36.0% in subsequent offspring. The most common allergens were Dermatophagoides pteronyssinus (DP), cockroach and Dermatophagoides farinae (DF). Allergic sensitization status of both parents and first offspring was related to the risk of allergic sensitization for subsequent offspring. The OR for the positive (father)-positive (first offspring) group was 1.92 (p < 0.01), ...Continue Reading

Citations

Jan 25, 2012·Clinical & Developmental Immunology·Peisong Gao
Apr 15, 2011·Allergologia et immunopathologia·G KarakayaA F Kalyoncu
Dec 17, 2014·Immunity, Inflammation and Disease·Priya TripathiXiaobin Wang
Sep 22, 2011·Journal of Korean Medical Science·Jihyun KimKangmo Ahn
May 10, 2017·Journal of Korean Medical Science·Myongsoon SungDae Hyun Lim

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