PMID: 11920487Mar 29, 2002Paper

Familial and second gastric carcinomas: a nationwide epidemiologic study from Sweden

Cancer
Kari Hemminki, Yongwen Jiang

Abstract

Familial risks in gastric carcinoma have been assessed mainly through case-control studies based on reported but not medically verified carcinomas in family members. Reliable data on familial risks are needed for prevention and clinical decisions. The authors used the nationwide Swedish Family-Cancer Database on 10.2 million individuals and more than 34,000 gastric carcinomas to calculate standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) for gastric carcinoma in offspring, from birth to 66 years old, by carcinomas in family members. In addition, SIRs for second gastric carcinomas were analyzed. Standardized incidence ratios for gastric carcinoma were 1.31 (95% CI, 0.97-1.70) and 1.47 (95% CI, 1.08-1.92) when a parent presented with gastric carcinoma or gastric adenocarcinoma, respectively. The risk was 1.59 (95% CI, 1.10-2.16) in offspring whose diagnosis was at ages older than 50 years. Offspring risk from parental corpus carcinoma was of borderline significance whereas that from cardia carcinoma was below unity. The sibling risk for gastric carcinoma was 3.16 (95% CI, 1.35-5.72) and 5.75 (95% CI, 2.07-11.26) when diagnosed before age 50. The population attributable proportion of familial gastric carcinom...Continue Reading

Citations

Jun 6, 2009·World Journal of Gastroenterology : WJG·Xue-Fu ZhouHui Wu
Nov 28, 2002·International Journal of Cancer. Journal International Du Cancer·Kari Hemminki, Xinjun Li
Apr 5, 2007·British Journal of Cancer·K HemminkiJ Ji

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