Abstract
Hemiplegic migraine (HM) is a rare variety of migraine with aura characterized by the presence of a motor weakness during the aura. Hemiplegic migraine has two main forms according to the familial history: patients with at least one first- or second-degree relative who has aura including motor weakness have familial hemiplegic migraine (FHM); patients without such familial history have sporadic hemiplegic migraine (SHM). The prevalence of HM is one in 10,000 with FHM and SHM being equally frequent. Typical HM attacks include a motor weakness that is always associated with other aura symptoms, the most frequent being sensory, visual and speech disorders. In addition, basilar-type symptoms occur in up to 70% of the patients. Severe attacks may occur in FHM as well as in SHM with prolonged hemiplegia, confusion, coma, fever and seizures. The clinical spectrum also includes permanent cerebellar signs (nystagmus, ataxia, dysarthria) and less frequently various types of seizures and intellectual deficiency. FHM is the only variety of the autosomal dominant migraine and all three know genes encode ion-transporters. A genetic diagnosis is now possible by screening the three known genes involved in FHM (CACNA1A, ATP1A2 and SCNA1). Progn...Continue Reading
References
Jun 21, 2001·Annals of Neurology·E E KorsM D Ferrari
Jul 7, 2001·The New England Journal of Medicine·A DucrosE Tournier-Lasserve
May 23, 2002·Brain : a Journal of Neurology·L L ThomsenM B Russell
Jan 23, 2003·Nature Genetics·Maurizio De FuscoGiorgio Casari
Feb 26, 2003·Neurology·Lise L ThomsenMichael B Russell
May 21, 2003·Archives of Neurology·E E KorsM D Ferrari
Sep 4, 2003·Annals of Neurology·Kaate R J VanmolkotArn M J M van den Maagdenberg
Feb 3, 2004·Annals of Neurology·Michael A MoskowitzTurgay Dalkara
Mar 9, 2004·Neuron·Arn M J M van den MaagdenbergMichel D Ferrari
Mar 4, 2005·The Journal of Biological Chemistry·Angelita TotteneDaniela Pietrobon
May 11, 2005·Neurology·Jean E SchoenenAlain Maertens de Noordhout
Aug 2, 2005·Lancet·Martin DichgansTim M Strom
Nov 18, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·C LamplV Limmroth
Jan 27, 2006·Annals of Neurology·K R J VanmolkotA M J M van den Maagdenberg
Citations
Aug 13, 2011·Neuroradiology·Isabelle MourandEric Thouvenot
Aug 12, 2009·Journal of Biological Physics·G RicciG Siciliano
Jan 30, 2010·The Journal of Headache and Pain·Irene ToldoPier Antonio Battistella
Dec 22, 2010·Cephalalgia : an International Journal of Headache·Irene ToldoPier Antonio Battistella
Mar 20, 2010·Headache·Eric GuedjPierre-Jean Weiller
May 19, 2012·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Elfriede KarnerMargarete Delazer
Aug 28, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Giuseppe LippiGianfranco Cervellin