PMID: 8973034Oct 1, 1996Paper

Familial atypical mole syndrome manifesting as polypoid melanoma: a case report and review of the Japanese literature

The Journal of Dermatology
N Misago, H Kohda

Abstract

A family with atypical mole syndrome which manifested as polypoid melanoma in one member is reported. A 46-year-old man presented with a polypoid tumor on his lower back, which was excised under clinical diagnosis of soft fibroma. The tumor proved to be polypoid melanoma. He was referred to our clinic, and examination revealed that he had the atypical mole syndrome phenotype. The clinicopathological screening of his first-degree relatives confirmed that his 58-year-old sister had the same phenotype. In addition to our discussion of the clinical significance of polypoid melanoma, we also attempted to elucidate the characteristics of the reported Japanese cases of melanomas with atypical moles from a survey of the literature, which revealed the following characteristics: 1) younger mean age than that of total Japanese melanoma cases, 2) sun sensitive skin, 3) unexpectedly and frequently observed familial incidence (Kraemer's D1 and D2), 4) frequent site of the melanoma on the trunk and none on the sole of the foot, and 5) high incidence of superficial spreading melanoma and nodular melanoma, and 6) no cases of acral lentiginous melanoma.

References

Sep 9, 1992·JAMA : the Journal of the American Medical Association
Feb 1, 1992·The American Journal of Dermatopathology·K HaraT Ikeya
Nov 1, 1991·The Journal of Dermatology·N MisagoH Kohda
May 1, 1989·The Journal of Investigative Dermatology·A Kukita, K Ishihara
Oct 1, 1989·Journal of the American Academy of Dermatology·S B GruberG C Roush
Jun 1, 1988·Archives of Dermatology·T B Fitzpatrick
Dec 18, 1986·The New England Journal of Medicine·K H KraemerW H Clark
Jun 1, 1981·American Journal of Clinical Pathology·E A ManciS J Soong
Aug 1, 1995·The British Journal of Dermatology·P KieneR Fölster-Holst
Dec 1, 1994·Human Molecular Genetics·C MacGeochN K Spurr
Aug 1, 1994·Melanoma Research·J A Newton BishopD T Bishop
Dec 1, 1993·Journal of the American Academy of Dermatology·J A NewtonA Swerdlow

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Citations

Jan 29, 2000·The British Journal of Dermatology·G Fabrizi, G Massi

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