Familial autoimmunity and polyautoimmunity in 60 Brazilian Midwest patients with systemic sclerosis

Revista brasileira de reumatologia
Alex Magno Coelho HorimotoIzaias Pereira da Costa

Abstract

Systemic sclerosis (SSc) is a connective tissue disease of unknown etiology, characterized by a triad of vascular injury, autoimmunity and tissue fibrosis. It is known that a positive family history is the greatest risk factor already identified for the development of SSc in a given individual. Preliminary observation of a high prevalence of poliautoimmunity and of familial autoimmunity in SSc patients support the idea that different autoimmune phenotypes may share common susceptibility variants. To describe the frequency of familial autoimmunity and poliautoimmunity in 60 SSc patients in the Midwest region of Brazil, as well as to report the main autoimmune diseases observed in this association of comorbidities. A cross-sectional study with recruitment of 60 consecutive patients selected at the Rheumatology Department, University Hospital, Medicine School, Federal University of Mato Grosso do Sul (FMUFMS), as well as interviews of their relatives during the period from February 2013 to March 2014. A frequency of 43.3% of poliautoimmunity and of 51.7% of familial autoimmunity in SSc patients was found. Patients with presence of poliautoimmunity and familial autoimmunity presented primarily the diffuse form of SSc, but this indi...Continue Reading

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Citations

Aug 2, 2016·Revista Brasileira De Reumatologia·Cristiane Kayser
Oct 13, 2016·Arthritis Research & Therapy·Chang-Fu KuoMichael Doherty

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