Familial chronic lymphocytic leukemia

Seminars in Oncology
Gabrielle S SellickR S Houlston

Abstract

The role of inherited genetic factors in the etiology of chronic lymphocytic leukemia (CLL) and other B-cell lymphoproliferative disorders (LPDs) is now well established. Significant familial aggregation of CLL and B-cell LPDs has been demonstrated, but the mode of inheritance is unknown. Identifying genes that when mutated confer an increased risk of these diseases is of immediate clinical relevance in terms of primary and secondary interventions. Furthermore, their identification provides for a greater understanding of the mechanisms of B-cell tumorigenesis in general. Here we review the current status of knowledge relating to inherited susceptibility to CLL and the strategies that are being employed to identify disease-causing mutations.

Citations

Sep 2, 2008·Nature Genetics·Maria Chiara Di BernardoRichard S Houlston
Nov 21, 2007·Hematology·Lynn R Goldin, Susan L Slager
Aug 18, 2012·Haematologica·Maria Chiara Di BernardoRichard S Houlston
Oct 6, 2009·Expert Review of Hematology·Jennifer R Brown
Apr 13, 2010·Current Opinion in Genetics & Development·Richard S Houlston
May 15, 2013·British Journal of Haematology·Georgina P SavaRichard S Houlston
Nov 2, 2007·International Journal of Cancer. Journal International Du Cancer·Helena M VerkooijenChristine Bouchardy
Nov 21, 2007·British Journal of Haematology·Lynn R Goldin, Neil E Caporaso
May 28, 2008·British Journal of Haematology·Stephen J FullerJames S Wiley
Oct 19, 2007·British Journal of Haematology·Brian J ScaglioneElizabeth S Raveche
Oct 27, 2007·British Journal of Haematology·Christoph PlassAlbert de la Chapelle
May 11, 2007·Clinical Genetics·S A GrafN S Young
Jun 18, 2010·British Journal of Haematology·Dalemari Crowther-SwanepoelRichard S Houlston
Sep 21, 2010·Cytometry. Part B, Clinical Cytometry·Erica SalernoElizabeth Raveche
Sep 6, 2011·Clinical Lymphoma, Myeloma & Leukemia·Pareen J ShenoyChristopher R Flowers
Oct 1, 2015·PloS One·James E HayesRobert J Klein
Aug 9, 2013·Therapeutic Advances in Hematology·Jennifer R Brown

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