Familial clustering of breast and prostate cancer and risk of postmenopausal breast cancer in the Women's Health Initiative Study

Cancer
Jennifer L Beebe-DimmerMichael S Simon

Abstract

Evidence suggests that the risk of breast and prostate cancer is increased among those with a family history of the same disease and particularly among first-degree relatives. However, less is known about the relationship between breast and prostate cancer within families and particularly among minority populations. Analyses of participants in the Women's Health Initiative observational cohort who were free of breast cancer at the time of their baseline examination were conducted. Subjects were followed for breast cancer through August 31, 2009. A Cox proportional hazards regression modeling approach was used to estimate the risk of breast cancer associated with a family history of prostate cancer, breast cancer, and both among first-degree relatives. There were 78,171 eligible participants, and 3506 breast cancer cases were diagnosed during the study period. A family history of prostate cancer was associated with a modest increase in breast cancer risk after adjustments for confounders (adjusted hazard ratio [aHR], 1.14; 95% confidence interval [CI], 1.02-1.26). In a separate analysis examining the joint impact of both cancers, a family history of both breast and prostate cancer was associated with a 78% increase in breast can...Continue Reading

References

Apr 15, 1995·American Journal of Epidemiology·A S WhittemoreT Stamey
Jul 5, 1995·Journal of the National Cancer Institute·S D IsaacsP C Walsh
Dec 21, 1994·Journal of the National Cancer Institute·T A SellersA R Folsom
May 29, 1997·International Journal of Cancer. Journal International Du Cancer·P D PharoahB A Ponder
Sep 25, 1997·International Journal of Cancer. Journal International Du Cancer·E NegriF Parazzini
Sep 8, 1998·Epidemiology·C RodríguezC W Heath
Sep 26, 2000·Cancer·H GrönbergM Emanuelsson
Apr 20, 2001·Maturitas·B S Hulka, P G Moorman
Oct 9, 2001·Epidemiologic Reviews·J L Stanford, E A Ostrander
Nov 15, 2002·Genetic Epidemiology·Agnes B Baffoe-BonnieHrafn Tulinius
Dec 11, 2002·American Journal of Human Genetics·Stephen M EdwardsUNKNOWN British Association of Urological Surgeons Section of Oncology
Oct 21, 2003·International Journal of Cancer. Journal International Du Cancer·Deborah Watkins BrunerPaul Engstrom
Oct 25, 2003·Annals of Epidemiology·Jennifer HaysJacques E Rossouw
Oct 25, 2003·Annals of Epidemiology·J David CurbUNKNOWN WHI Morbidity and Mortality Committee
Sep 24, 2004·JAMA : the Journal of the American Medical Association·Harvey J MurffSapna Syngal
Nov 20, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J Lorenzo Bermejo, K Hemminki
Dec 4, 2004·International Journal of Cancer. Journal International Du Cancer·Eva NegriCarlo La Vecchia
Jun 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael S SimonAnn G Schwartz
Jun 15, 2007·Journal of the National Cancer Institute·Laufey TryggvadóttirHrafn Tulinius
Aug 19, 2007·British Journal of Cancer·I AgalliuJ L Stanford
Nov 7, 2007·European Urology·Joost L Boormans, Fritz H Schröder
Jul 16, 2008·International Journal of Cancer. Journal International Du Cancer·Maurice P ZeegersPiet A van den Brandt
Feb 4, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ilir AgalliuRobert D Burk
Apr 7, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A BrandtK Hemminki
Apr 21, 2012·British Journal of Cancer·D LeongamornlertZ Kote-Jarai
May 15, 2012·Journal of Medical Genetics·Hassan RoudgariMahdi Fallah
Apr 10, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elena CastroRosalind Eeles
Jul 26, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F TuratiC La Vecchia
Dec 7, 2013·Expert Review of Anticancer Therapy·Federica TuratiCarlo La Vecchia
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Mar 19, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jan 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A BrandtK Hemminki

❮ Previous
Next ❯

Citations

Apr 9, 2015·British Journal of Hospital Medicine·Ros Levenson
Oct 31, 2018·VASA. Zeitschrift für Gefässkrankheiten·Noemi GalasPayman Majd
May 16, 2020·Cancer Biotherapy & Radiopharmaceuticals·Chunxin QinZhiyong Zhan
Jan 2, 2016·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Traci N BetheaJulie R Palmer
Aug 8, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lauren BarberLorelei A Mucci
Aug 7, 2019·Trends in Molecular Medicine·Priscila F SlepickaCamila O Dos Santos
Feb 9, 2017·The Breast : Official Journal of the European Society of Mastology·Jun-Long SongSheng-Rong Sun

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.