Familial Colorectal Cancer Type X (FCCTX) and the correlation with various genes-A systematic review

Current Problems in Cancer
Mahdieh NejadtaghiKeihan Ghatreh Samani

Abstract

Familial Colorectal Cancer Type X (FCCTX) is a type of hereditary nonpolyposis colorectal cancer in accordance to Amsterdam criteria-1 for Lynch syndrome, with no related mutation in mismatch repair gene. FCCTX is microsatellite stable and is accounted for 40% of families with Amsterdam criteria-1 with a high age of onset. Thus, the carcinogenesis of FCCTX is different compared to Lynch syndrome. In addition to the microsatellite stability and the presence of less predominant tumors in proximal colon, various clinical features have also been associated with FCCTX in comparison with Lynch syndrome such as no increased risk of extra-colonic cancers, older age of diagnosis and higher adenoma/carcinoma rate. Genetic etiology of this type of cancer which is autosomal dominant is unknown. In this review, we focus on the genes and their variants identified in this type of CRC. In order to find out the correlation between FCCTX and various genes database such as PubMed and PMC, search engine such as Google scholar and portals such as Springer and Elsevier have been searched. Based on our literature search, several studies suggest that FCCTX is a heterogeneous type of disease with different genetic variants. Recent studies describe the ...Continue Reading

References

Jun 1, 1995·The Journal of Clinical Investigation·B M EversJ Li
Nov 25, 1997·Japanese Journal of Cancer Research : Gann·Y ImaiT Ishikawa
Oct 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·Georgia L WiesnerSanford D Markowitz
May 13, 2004·PLoS Biology·Adam AmsterdamNancy Hopkins
Apr 28, 2005·JAMA : the Journal of the American Medical Association·Noralane M LindorDaniela Seminara
Oct 26, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xavier LlorUNKNOWN Gastrointestinal Oncology Group of the Spanish Gastroenterological Association
Aug 5, 2006·Alimentary Pharmacology & Therapeutics·A O O ChanB C Y Wong
Sep 9, 2006·Science·Tobias SjöblomVictor E Velculescu
Jan 18, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laura ValleMiguel Urioste
Feb 24, 2007·The EMBO Journal·Toshihiko ToyofukuMasatsugu Hori
Oct 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ana Sánchez-de-AbajoTrinidad Caldes
Oct 17, 2007·Genes & Development·Anil K Rustgi
Mar 8, 2008·Gastroenterology·Rodrigo Jover, Antoni Castells
Mar 28, 2008·International Journal of Cancer. Journal International Du Cancer·Shuji OginoCharles S Fuchs
Jul 22, 2008·Nature Genetics·Kelly A McGowanGregory S Barsh
Jan 29, 2009·International Journal of Cancer. Journal International Du Cancer·Annette GyllingPaivi Peltomäki
Apr 7, 2009·Biochimica Et Biophysica Acta·Antje M RichterReinhard H Dammann
Oct 2, 2009·Surgical Oncology Clinics of North America·Noralane M Lindor
Jun 17, 2010·Cancer Research·Courtney Gray-McGuireGeorgia L Wiesner
Sep 8, 2010·The Journal of Cell Biology·Marie-Françoise O'DonohuePierre-Emmanuel Gleizes
Nov 26, 2010·Annual Review of Pathology·Eric R Fearon
Jun 7, 2011·Gastroenterology·Taina T NieminenPäivi Peltomäki
Aug 13, 2011·Familial Cancer·Inês FranciscoAntónio Dias Pereira
Feb 9, 2012·Cold Spring Harbor Perspectives in Medicine·Gera NeufeldOfra Kessler
Mar 8, 2012·International Journal of Cancer. Journal International Du Cancer·Tomohiko SaseHironobu Sasano
Aug 10, 2012·Journal of Human Genetics·Jérémie H LefevreWalter F Bodmer
Oct 27, 2012·Seminars in Cell & Developmental Biology·Michael Rehman, Luca Tamagnone
Dec 19, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Christina TherkildsenMef Nilbert

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenomatous Polyposis Coli

Adenomatous polyposis coli is a protein encoded by the APC gene and acts as a tumor suppressor. Discover the latest research on adenomatous polyposis coli here.

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.