Familial correlations and inter-relationships of four asthma-associated quantitative phenotypes in 320 French EGEA families ascertained through asthmatic probands

European Journal of Human Genetics : EJHG
E BouzigonF Demenais

Abstract

Asthma is a complex disease, associated with biological and physiological phenotypes including immunoglobulin E (IgE) levels, sum of positive skin prick tests to allergens (SPTQ), eosinophil counts (EOS) and percent predicted forced expiratory volume in 1 s (%FEV1). We investigated the patterns of familial correlations and the inter-relationships of these four quantitative phenotypes, using the general class D regressive model, in 320 French EGEA nuclear families ascertained through 204 offspring (set A) and 116 parents (set B). Familial correlations of IgE and SPTQ were consistent with a model including no spouse correlation and equal parent-offspring and sib-sib correlations (rhoPO = rhoSS = 0.25 for IgE and 0.15 for SPTQ), this model being compatible with an additive polygenic model in the whole sample and the two family subsets A and B. Different patterns of familial correlations of EOS and %FEV1 were observed in these two sets. In set A, the best fitting model included no spouse correlation and equality of parent-offspring and sib-sib correlations (rhoPO = rhoSS = 0.14 for EOS and 0.23 for %FEV1). In set B, EOS had only a significant rhoSS of 0.28, while %FEV1 had significant rhoMO of 0.28 and rhoSS of 0.16. Analysis of sh...Continue Reading

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Citations

Aug 11, 2007·American Journal of Respiratory and Critical Care Medicine·Craig C TeerlinkLisa A Cannon-Albright
Jun 19, 2009·Genes and Immunity·H AschardUNKNOWN EGEA cooperative group
Mar 22, 2015·Revue des maladies respiratoires·E BouzigonV Siroux
Dec 17, 2014·Immunity, Inflammation and Disease·Priya TripathiXiaobin Wang
Aug 27, 2013·Current Opinion in Allergy and Clinical Immunology·Rachel NadifRegis Matran

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