PMID: 8589615Dec 1, 1995Paper

Familial cutaneous melanoma

Melanoma Research
L LucchinaA J Sober

Abstract

Family history is an important risk factor for cutaneous malignant melanoma. We evaluated the clinical characteristics of patients with cutaneous familial melanoma. A chart review was conducted, including all patients who presented to Massachusetts General Hospital Pigmented Lesion Clinic over an 8-year period. A total of 102 patients from 49 families were confirmed with shaving cutaneous melanoma. Eighty-two per cent had a personal and/or family history of dysplastic naevi. Within families, subsequent affected patients had thinner primary lesions with substantially lower median thickness than those diagnosed first. Seventeen per cent had multiple primary melanomas, with the median thickness of subsequent primaries being much lower than that of the first primary lesions. The mean thickness of primary lesions in patients with one primary lesion was marginally significantly greater than that in patients with multiple primaries. Verification of family history is essential given the implications of a positive family history. Screening family members of all patients with cutaneous melanoma and surveillance examinations for all patients with cutaneous melanoma is recommended.

Citations

Feb 19, 2002·Clinics in Dermatology·Cybele FishmanArthur J Sober
Aug 6, 1996·Proceedings of the National Academy of Sciences of the United States of America·M G FitzGeraldD A Haber
Sep 14, 2011·Annals of Surgical Oncology·Rajmohan MuraliUNKNOWN GEM Study Group
Sep 11, 2008·Melanoma Research·Alessandra ChiarugiPaolo Carli
Mar 22, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·E NagoreC Guillen
Sep 15, 2001·Dermatologic Clinics·M G Fleming
Apr 16, 2015·PloS One·Iván Márquez-RodasUNKNOWN Spanish Multidisciplinary Group of Melanoma (GEM)
May 5, 2000·The Cochrane Database of Systematic Reviews·T CrosbyM D Mason
Apr 29, 1998·Journal of Cutaneous Medicine and Surgery·D HoggN J Lassam
Jan 23, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·S MylleL Brochez
Jun 15, 2021·Frontiers in Oncology·Cristian ScatenaSara Tomei

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