Familial expression of anti-Escherichia coli outer membrane porin C in relatives of patients with Crohn's disease

Gastroenterology
L MeiHuiying Yang

Abstract

Crohn's disease (CD) is a genetically complex disorder with strong familial aggregation. Pathogenesis appears to involve dysregulation of the immune response to endogenous bacteria. Anti-Escherichia coli outer membrane porin C (anti-OmpC) expression reflects an exaggerated response to commensal bacteria and occurs with higher frequency in CD. The aim of this study was to determine whether there is familial aggregation and genetic determination of anti-OmpC expression in CD families. Study groups consisted of 787 CD patients, 389 ulcerative colitis (UC) patients, 619 unaffected relatives, and 216 healthy controls. Serum anti-OmpC was detected by enzyme-linked immunosorbent assay. CD patients had a greater percentage of anti-OmpC than UC patients and healthy controls. Anti-OmpC expression was more frequent in unaffected relatives from CD-only or mixed families, compared with healthy controls (P = .002 and .0001, respectively), and it was more frequent in UC patients from mixed families than those from UC-only families (P = .02). There was a significant familiality in anti-OmpC expression: P = .02 for qualitative concordance and P < .0001 for quantitative intraclass correlation. The heritability estimate for anti-OmpC level was .3...Continue Reading

Associated Clinical Trials

Citations

Feb 21, 2008·Inflammatory Bowel Diseases·David Underhill, Jonathan Braun
Aug 23, 2008·Inflammatory Bowel Diseases·Dermot P B McGovernJerome I Rotter
Oct 1, 2009·Immunogenetics·Jill A HollenbachElizabeth A Trachtenberg
Dec 12, 2007·Antimicrobial Agents and Chemotherapy·Sreedhar SubramanianBarry J Campbell
Nov 26, 2009·Arthritis Research & Therapy·Matthew L MundwilerMichael H Weisman
Jul 15, 2011·Clinical and Experimental Gastroenterology·Cyrus P TamboliAmar Patel
Sep 26, 2013·Future Microbiology·Emma J SmithDavid J Clarke
Nov 28, 2007·Annual Review of Pathology·Jonathan Braun, Bo Wei
May 4, 2007·Inflammatory Bowel Diseases·Nathalie Rolhion, Arlette Darfeuille-Michaud
Jan 17, 2017·Clinical & Translational Immunology·Wilhelmina Maria Cornelia TimmermansMenno Cornelis van Zelm
Jul 20, 2007·Inflammatory Bowel Diseases·Laurent Peyrin-BirouletMathias Chamaillard
May 3, 2014·Inflammatory Bowel Diseases·Dario SorrentinoGianluca Benevento
Nov 10, 2011·Inflammatory Bowel Diseases·Lani PrideauxMichael A Kamm
Jan 30, 2007·Inflammatory Bowel Diseases·Konstantinos A PapadakisStephan R Targan
Feb 20, 2007·Inflammatory Bowel Diseases·Giovanni LatellaRenzo Caprilli
Jan 12, 2016·Inflammatory Bowel Diseases·Dario Sorrentino
Dec 8, 2017·Journal of Pediatric Gastroenterology and Nutrition·Sandra S WrightLee A Denson
Feb 2, 2018·Journal of Medicinal Food·Michael RohrSampath Parthasarathy
Aug 29, 2018·Expert Review of Molecular Diagnostics·Hu ZhangBo Shen
Jan 28, 2009·Journal of Pediatric Gastroenterology and Nutrition·Ryan CarvalhoCarmen Cuffari
Jan 1, 2015·F1000Research·Jonathan Kaunitz, Piyush Nayyar
Aug 31, 2006·Current Opinion in Infectious Diseases·Sreedhar SubramanianJonathan Michael Rhodes
Nov 30, 2006·Current Opinion in Gastroenterology·Nicolas Barnich, Arlette Darfeuille-Michaud
Nov 16, 2006·Current Gastroenterology Reports·David H Bruining, Edward V Loftus
Apr 2, 2008·Current Gastroenterology Reports·David H Bruining, Edward V Loftus
Apr 2, 2008·Current Gastroenterology Reports·R Balfour Sartor, Marcus Muehlbauer
Dec 17, 2008·Expert Review of Gastroenterology & Hepatology·Iris Dotan
Jul 5, 2008·Expert Review of Molecular Diagnostics·Marie-Alice MeuwisMarie-Paule Merville
Sep 19, 2014·World Journal of Gastroenterology : WJG·Jessica CarrièreHang Thi Thu Nguyen
Jul 1, 2015·Current Gastroenterology Reports·Gerhard Rogler, Luc Biedermann
Feb 18, 2011·Gut Microbes·Mahendrasingh RamjeetLeonardo H Travassos
Oct 31, 2014·World Journal of Gastroenterology : WJG·Zi-Kai WangLi-Hua Peng
Jan 27, 2016·World Journal of Gastroenterology : WJG·Keiichi MitsuyamaTakuji Torimura
Jun 15, 2006·World Journal of Gastroenterology : WJG·Marla-C DubinskyJerome-I Rotter
Jun 8, 2018·Frontiers in Medicine·Peilin ZhangRusty Kruzelock
Aug 19, 2015·Gastroenterology·Marla Dubinsky, Jonathan Braun

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