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Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy

Acta Neuropathologica

Jan 8, 2020

Isidro FerrerJosé Antonio Del Rio

Abstract

Globular glial tauopathy (GGT) is a progressive neurodegenerative disease involving the grey matter and white matter (WM) and characterized by neuronal deposition of hyper-phosphorylated, abnormally conformed, truncated, oligomeric 4Rtau in neurons and in glial cells forming typical glo...read more

Mentioned in this Paper

MOG protein, human
brown adipose tissue uncoupling protein
2',3'-Cyclic-Nucleotide Phosphodiesterases
Cardiomyopathies, Primary
OLIG1 protein, human
GJA1 gene
ALDH1L1 protein, human
SLC1A2 protein, human
Neuropathology
White Matter
4
1
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© 2020 Meta ULC. All rights reserved

Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy

Acta Neuropathologica

Jan 8, 2020

Isidro FerrerJosé Antonio Del Rio

PMID: 31907603

DOI: 10.1007/s00401-019-02122-9

Abstract

Globular glial tauopathy (GGT) is a progressive neurodegenerative disease involving the grey matter and white matter (WM) and characterized by neuronal deposition of hyper-phosphorylated, abnormally conformed, truncated, oligomeric 4Rtau in neurons and in glial cells forming typical glo...read more

Mentioned in this Paper

MOG protein, human
brown adipose tissue uncoupling protein
2',3'-Cyclic-Nucleotide Phosphodiesterases
Cardiomyopathies, Primary
OLIG1 protein, human
GJA1 gene
ALDH1L1 protein, human
SLC1A2 protein, human
Neuropathology
White Matter
4
1

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Tau toxicity has been implicated in the emergence of synaptic dysfunction in Alzheimer's disease. Here is the latest research on Tau Toxicity in the Synapses.

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Frontiers in Aging Neuroscience

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