Familial glomerulonephropathy in the Bullmastiff

Veterinary Pathology
M L CasalP S Henthorn

Abstract

Glomerular disease was diagnosed by histopathologic examination in 11 related Bullmastiff dogs, and clinical and laboratory data were collected retrospectively. Four female and seven male dogs between the ages of 2.5 and 11 years were affected. Clinical signs, including lethargy and anorexia, were nonspecific and occurred shortly before death or euthanasia. In five affected dogs serial blood samples were obtained, and dramatically elevated blood urea nitrogen and creatinine levels were demonstrated up to 2.75 years before death. Protein-creatinine ratios were elevated in six of six dogs and were above normal 3.5 years before death in one dog. The kidneys appeared grossly normal to slightly smaller than normal at necropsy. Histologic abnormalities of the kidneys were consistent with chronic glomerulonephropathy with sclerosis. Examination of the pedigrees of related affected dogs yielded evidence supporting an autosomal recessive mode of inheritance.

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Citations

Jan 22, 2011·The Veterinary Clinics of North America. Small Animal Practice·Meryl P Littman
Feb 9, 2010·Journal of Veterinary Internal Medicine·R LavouéD Peeters
Jan 23, 2015·Advances in Bioinformatics·Md Mahmudul HasanMd Zakir Hossain
Apr 4, 2021·Animals : an Open Access Journal From MDPI·Maria Alfonsa CavaleraAndrea Zatelli

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Methods Mentioned

BETA
light microscopy
biopsy

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